缺氧诱导因子1α单核苷酸多态性与四川地区汉族人群子宫颈癌相关性研究  

Relationship between Polymorphism of Hypoxia Inducible Factor-1α and Cervical Cancer in Han Population in Sichuan Province of China

作　　者：柴丹[1] 陈亚丽[1] 郑艾[1] 刘延友[2] 褚艳侠[1] 韩玲[1] 

机构地区：[1]四川大学华西第二医院妇产科,成都610041 [2]四川大学卫生部时间生物学重点实验室,成都610041

出　　处：《四川大学学报（医学版）》2010年第4期674-677,共4页Journal of Sichuan University(Medical Sciences)

摘　　要：目的探讨缺氧诱导因子-1α(hypoxia inducible factor-1α,HIF-1α)基因多态性与中国四川地区汉族人群宫颈癌易感性、临床分期及组织病理学特征间的相关性。方法采用聚合酶链反应-限制性片段长度多态性分析方法,检测该地区97例宫颈癌和117例正常宫颈组织HIF-1αC1772T位点基因型的分布。结果宫颈癌组HIF-1αC1772T位点T等位基因频率高于对照组(P<0.01);T/T和T/C基因型携带者患宫颈癌风险增加。HIF-1αC1772T位点各基因型在不同临床分期及组织病理学特征的宫颈癌患者间分布差异无统计学意义(P>0.05)。结论①HIF-1αC1772T位点T等位基因可能是四川地区汉族女性罹患宫颈癌的分子遗传学标记;②HIF-1αC1772T位点SNP可能与四川地区汉族女性宫颈癌进展无关。Objective To investigate the relationship between single nucleotide polymorphism(SNP) of hypoxia inducible factor-1α(HIF-1α) C1772T and genetic susceptibility to and clinical-pathological features of cervical cancers in Han population in Sichuan province of China.Methods A case control study was undertaken in Sichuan province of China,with 97 patients with uterine cervical cancer as case group and 117 negative for intraepithelial lesion or malignancy(NILM) patients as control group.Their gene types in HIF-1α C1772T were identified with a combination of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Results The distribution of the frequencies of T/T,T/C and C/C genotypes in the two groups differed significantly(P0.05).Conclusion T/C and T/T genotypes of HIF-1α C1772T are genetic susceptibility factors for cervical cancer in Han population in Sichuan province of China.HIF-1α C1772T SNP probably has no relationship with clinical-pathological features of cervical cancer.

关 键 词：宫颈癌 缺氧诱导因子-1αC1772T位点 单核苷酸多态性 四川地区汉族女性 

分 类 号：R737.33[医药卫生—肿瘤]