荷移分光光度法测定酒石酸美托洛尔  

Spectrophotometric determination of metoprolol tartrate based on a charge transfer reaction

作　　者：于丽丽[1] 刘佳川[1] 康剑锋[1] 李华侃[1] 

机构地区：[1]辽宁医学院化学教研室室,锦州121001

出　　处：《分析试验室》2010年第10期84-86,共3页Chinese Journal of Analysis Laboratory

摘　　要：研究了酒石酸美托洛尔与紫色素之间的荷移反应。确定了反应条件,建立了一种测定酒石酸美托洛尔的荷移分光光度法。酒石酸美托洛尔与紫色素在乙醇介质中,室温条件下即可形成稳定的1∶1型荷移络合物,该络合物的最大吸收波长为540 nm,表观摩尔吸光率为6.83×103L.mol-1.cm-1。酒石酸美托洛尔质量浓度在10~80 mg/L范围内服从比耳定律,相关系数为0.9991。相对标准偏差为1.3%(n=11),回收率为99.3%~102.7%。The charge transfer reaction between metoprolol tartrate and purpurin was investigated by spectrophotometry.A simple and rapid method for the determination of metoprolol tartrate has been developed.Results show that the composition ratio of charge transfer complex is 1∶1 in ethanol solution at room temperature.The apparent molar Absorptivity of the complex is 6.83×103 L·mol-1·cm-1 at 540 nm.Beer′s law is obeyed in the range of 10～80 mg/L of metoprolol tartrate with the correlation coefficient of 0.9991.The relative standard deviation is 1.3%(n = 11).The recoveries are 99.3%～102.7%.

关 键 词：荷移反应 分光光度法 酒石酸美托洛尔 紫色素 

分 类 号：R927.2[医药卫生—药学]