血浆一氧化氮水平和脑血管反应性与进展性卒中的关系研究  被引量:3

Plasma level of nitric oxide and cerebrovascular reactivity are associated with stroke in progression

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作  者:彭忠兴[1] 黄旭明[1] 洪铭范[1] 余青云[1] 苏全喜[1] 张明兴[1] 桀骜[1] 

机构地区:[1]广东药学院附属第一医院神经内科,广州510080

出  处:《脑与神经疾病杂志》2010年第4期244-247,共4页Journal of Brain and Nervous Diseases

基  金:广东省卫生厅医学科研基金资助(A2007312)

摘  要:目的探讨一氧化氮(NO)和脑血管反应性(CVR)与进展性卒中(SIP)的关系。方法对发病24h内住院经头颅CT和/或MRI检查证实为大脑中动脉(MCA)供血区脑梗死患者,以斯堪的那维亚卒中量表(SSS)在住院72h内评分较入院时下降2分以上者判定为SIP患者,共50例;在住院72h内评分较入院时不下降或下降小于2分者判定为非SIP患者,共61例;以无脑梗死的体检者为正常对照组(52例)。采用硝酸还原酶法测定两组NO血浆水平,采用经颅多普勒超声结合屏气试验获取屏气指数(BHI)以评价CVR。结果 SIP组NO水平(40.15±4.73)显著低于非SIP组(56.55±8.35)和对照组(65.5±7.40)(P<0.00l),SIP组BHI(1.01±0.26)低于对照组(1.41±0.34)和非SIP组(1.18±0.30)(P<0.00l),BHI与NO血浆水平呈正相关(r=0.29,P=0.034)。结论 SIP患者的CVR降低与NO水平下降有相关性,CVR的下降是导致SIP的危险因素之一,检测NO水平和BHI有助于预测SIP发生的可能性,为临床治疗决策和预后判断具有重要意义。Objective To investigate the relationship of nitric oxide(NO),cerebrovascular reactivity(CVR)and stroke in progression(SIP).Methods With the Scandinavian Stroke Scale(SSS)as a standard that the score of patient decreased by 2 points or more within 72 hours to diagnose SIP,we examined the patients who were diagnosed as middle cerebral artery infarction with head CT and /or MRI within 24h.So 50 patients were diagnosed as SIP.And the score of patient decreased less than 2 points as NSIP(61 cases).The volunteers were free of cerebral infarction as normal control group(52 cases).Plasma NO levels were assayed by nitrate reductase,we evaluated CVR with transcranial doppler ultrasonography and breath test for breath-holding index(BHI).Results SIP group NO levels(40.15 ± 4.73)were significantly lower than the NSIP group(56.55 ± 8.35)and the control group(65.5 ± 7.40)(P <0.00l),SIP group BHI(1.01 ± 0.26)was significantly lower than the NSIP group(1.18 ± 0.30)and the control group(1.41 ± 0.34)(P<0.001),BHI and plasma levels of NO were positively correlated(r = 0.29,P = 0.034).Conclusion There are some correlations between the CVR reduction and NO reduction in SIP patients.The CVR drop is one of the leading risk factor for SIP.BHI can help to predict the likelihood of SIP,it is important for the clinical treatment decisions and prognosis

关 键 词:进展性卒中 一氧化氮 脑血管反应性 

分 类 号:R743.3[医药卫生—神经病学与精神病学]

 

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