伊立替康及CF联合5-FU或FUDR治疗消化道肿瘤毒副作用的比较  

Comparison of the Adverse Effects of Irinotecan and Calcium Folinate Combined with 5-fluorouracil or Floxuridine Using Different Injection Ways for Advanced Gastrointestinal Cancer

作　　者：赵东丽[1] 袁苏徐[1] 程雪[1] 胡文杰[1] 郝艳[1] 

机构地区：[1]苏州大学附属第一医院肿瘤科,215006

出　　处：《实用癌症杂志》2010年第5期497-499,共3页The Practical Journal of Cancer

摘　　要：目的评价伊立替康及CF联合5-FU或FUDR的不同给药方案治疗晚期消化道恶性肿瘤的毒副作用。方法回顾性收集伊立替康及CF联合5-FU或FUDR的不同给药方案治疗晚期消化道肿瘤88例的临床资料,按化疗方案分为3组。A组33例,方案为:伊立替康150～180mg/m2静脉滴注d1,CF200mg/m2静脉滴注d1～2,5-FU400mg/m2静脉推注d1～2,5-FU600mg/m2持续静脉推注22hd1～2,每2周重复;B组27例,方案为:伊立替康240～270mg/m2静脉滴注d1,CF200mg/m2静脉滴注d1～5,5-FU750mg/m2静脉滴注d1～5,每3周重复;C组28例,方案为:伊立替康150～180mg/m2静脉滴注d1,CF200mg/m2静脉滴注d1～2,FUDR400mg/m2静脉推注d1～2,FUDR600mg/m2持续静脉推注22hd1～2,每2周重复。毒副作用指标为:白细胞减少、迟发性腹泻、口腔黏膜炎。结果 A组与C组白细胞减少的发生率高于B组(均P<0.05),而A组与C组之间无差别;迟发性腹泻及口腔黏膜炎的发生率3组间无明显差别。结论 5-FU静脉滴注组的白细胞减少的发生率低于持续静脉推注组。Objective To evaluate the adverse effects of different regimens of irinotecan (CPT-11)and calcium folinate (CF) combined with 5-fluorouracil (5-FU) or floxuridine (FUDR) in the treatment of advanced gastrointestinal cancer.Methods The clinical data of 88 advanced gastrointestinal cancer patients who were treated using different regimens of CPT-11 and CF combined with 5-FU or FUDR were retrospective collected and these cases were grouped with three groups according to chemotherapy regimens.33 patients in the group A received CPT-11 at the dose of 150～180 mg/m2 as an intravenous infusion on day 1;CF was given at the dose of 200 mg/m2 as an intravenous infusion,followed by 5-FU 400 mg/m2 as bolus,and then,600 mg/m2 as a 22 h continuous bolus,on days 1 and 2.The treatment was administered every 2 weeks.27 patients in the group B received CPT-11 at the dose of 240～270 mg/m2 as an intravenous infusion on day 1;CF was given at the dose of 200 mg/m2 as an intravenous infusion on days 1 to 5,followed by 5-FU 750 mg/m2 as an intravenous infusion on days 1 to 5.The treatment was administered every 3 weeks.28 patients in the group C received CPT-11 at the dose of 150～180 mg/m2 as an intravenous infusion on day 1;CF was given at the dose of 200 mg/m2 as an intravenous infusion,followed by FUDR 400 mg/m2 as bolus,and then,600 mg/m2 as a 22 h continuous bolus,on days 1 and 2.The treatment was administered every 2 weeks.Adverse effect indicators include leukopenia,diarrhea and oral mucositi.Results The incidence of leukopenia of group A and C is higher than that of group B (P<0.05).However,there is no significant difference between group A and C.The incidence of diarrhea and oral mucositis has no significant difference among them.Conclusion The incidence of leukopenia of intravenous infusion fluorouracil is lower than that of continuous bolus.

关 键 词：伊立替康 5-氟尿嘧啶 醛氢叶酸 氟脲苷 消化道肿瘤 毒副作用 

分 类 号：R735[医药卫生—肿瘤]