血清血管内皮生长因子在肝癌介入栓塞后的表达  

Expression of Serum Cascular Endothelial Growth Factor after Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma

作　　者：丁罡[1] 邵怿[2] 刘合代[1] 黄燕[1] 梁宏享[1] 赵其德[1] 

机构地区：[1]上海交通大学附属新华医院崇明分院肿瘤科,202150 [2]上海长航医院肿瘤科,200122

出　　处：《实用癌症杂志》2010年第5期464-466,共3页The Practical Journal of Cancer

基　　金：上海市卫生局基金资助项目(054117)

摘　　要：目的探讨血清血管内皮生长因子(VEGF)在肝癌栓塞化疗(TACE)后的表达水平和临床意义。方法分析63例肝细胞肝癌患者的血管造影结果和VEGF血清表达水平,采用ELISA法检测40例TACE前后患者血清VEGF的变化。结果 43例肿瘤富血管患者血清VEGF水平高于20例肿瘤乏血管患者[(136.80±52.13)pg/mlvs(62.30±31.17)pg/ml,P<0.05];患者肝动脉栓塞治疗前后血清VEGF分别为(87.41±43.16)pg/ml和(128.42±43.12)pg/ml,P<0.05.其中有36例患者血清VEGF水平在肝动脉栓塞治疗后升高,第二次血管造影发现27例新生肿瘤血管的患者血清VEGF水平显著升高(179.13±66.27)pg/ml。血清VEGF浓度明显升高的患者介入治疗疗效较差。结论肝癌TACE后肿瘤细胞表达VEGF增强,血清VEGF是影响肝癌栓塞化疗效果的因素之一。Objective To investigate the expression of serum vascular endothelial growth factor (VEGF) after TACE in patients with hepatocellular carcinoma.Methods We detected tumor blood vessels of 63 patients with HCC by angiography,and measured serum VEGF concentrations by ELISA before and 2 days after TACE.Results We found serum VEGF concentrations in hypervascular patients were higher than that in hypovascular patients [(136.80±52.13)pg/ml vs(62.30 ±31.17)pg/ml,P<0.05)].Serum VEGF concentrations in 36 patients ...

关 键 词：肝癌 栓塞化疗 血管内皮生长因子 肿瘤血管形成 

分 类 号：R735.7[医药卫生—肿瘤]