Inclusion Behavior of Dimer β-CyclodextrinBridged with Aspartic Acid Derivative  

Inclusion Behavior of Dimer (-Cyclodextrin Bridged with Aspartic Acid Derivative

作　　者：Le Xin SONG Coordination Chemistry Institute & State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093 

出　　处：《Chinese Chemical Letters》2001年第2期119-120,共2页中国化学快报（英文版）

摘　　要：The (β-cyclodextrin (CD) dimer bridged with aspartic acid (ASP) derivative, FITC-ASP(NH-(-CD)2 (Host, FITC=fluorescein-4-isothiocyanate), was synthesized. Fluorescence polarization study showed that the novel host formed an inclusion compound, [FITC-ASP(NH-(-CD)2]ATA, for which Kd was determined to be 5.0×10-6 mol/L by Beacon 2000 Analyzer, when ATA (Guest) = Adm-Trp-Arg-Arg-NH2 (Adm = 1-adamantanecarboxylic acid, Trp = tryptophan, Arg = arginine), where Kd is the dissociation constant in aqueous solution at 298 K.The (β-cyclodextrin (CD) dimer bridged with aspartic acid (ASP) derivative, FITC-ASP(NH-(-CD)2 (Host, FITC=fluorescein-4-isothiocyanate), was synthesized. Fluorescence polarization study showed that the novel host formed an inclusion compound, [FITC-ASP(NH-(-CD)2]ATA, for which Kd was determined to be 5.0×10-6 mol/L by Beacon 2000 Analyzer, when ATA (Guest) = Adm-Trp-Arg-Arg-NH2 (Adm = 1-adamantanecarboxylic acid, Trp = tryptophan, Arg = arginine), where Kd is the dissociation constant in aqueous solution at 298 K.

关 键 词：Β-CYCLODEXTRIN amino acid PEPTIDE inclusion compound fluorescence polarization. 

分 类 号：O631[理学—高分子化学]