Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology  

作　　者：Jun Cui Dong Hua Yang Xiang Jun Bi Zi Rong Fan Department of Gastroenterology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, Guangdong Province, China 

出　　处：《World Journal of Gastroenterology》2001年第1期136-139,共4页世界胃肠病学杂志（英文版）

基　　金：Supported by the Natural Science Foundation of Guangdong Province, No 990422

摘　　要：INTRODUCTIONThe mechanism that DNA hypomethylation leads toactivation of oncogene and occurrence of malignantneoplasm is being increasingly recognized byresearchers. Normal DNA methylation playsimportant role in stabilizing the phenotype of cell.DNA methylation status reduction and/or patternalteration are related to activation and abnormallyhigh expression of some oncogenes and cellularmalignancy[1-6]. c-fms oncogene encodes for colonystimulating factor 1 receptor (CSF-1R)[7], c-fms/CSF-1R was highly expressed in hepatocellularcarcinoma (HCC) tissue, but the mechanismremained obscure[8,9].

关 键 词：Adult Aged Blotting  Southern Carcinoma  Hepatocellular DNA Methylation Female Gene Expression Regulation  Neoplastic Humans Liver Liver Neoplasms Male Middle Aged Phenotype Receptor  Macrophage Colony-Stimulating Factor Research Support  Non-U.S. Gov't 

分 类 号：R735.7[医药卫生—肿瘤]