THE EXPRESSION OF RECEPTORS FOR VASOACTIVE INTESTINAL PEPTIDE AND SECRETIN IN COLON NEOPLASMS  

作　　者：唐承薇 Iza Biemond Hein W Verspaget Cornelis BHW Lamers 

机构地区：[1]Department of Gastroenterology, The First Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China

出　　处：《Chinese Journal of Cancer Research》2001年第4期280-283,共4页中国癌症研究（英文版）

基　　金：This work was supported by a Grant from Chinese National Science Research Foundation of China for the Excellent Young Scientist(No. 39725012).

摘　　要：Objective: To investigate the expression of the receptors for vasoactive intestinal peptide (VIP) and secretin in colon cancer. Methods: This study visualized and characterized the receptors for VIP and secretin in the sequence of human tumor-free colon, adenoma, carcinoma, liver metastasis using storage phosphor autoradiography. Results: Receptors for VIP and secretin were demonstrated in tumor-free colon and colon tumors. A decrease in affinity of VIP receptors was shown in the colonic liver metastasis (Kd = 3.30 nmol) when compared with tumor-free colon (Kd = 0.82 nmol). An up-regulation of receptors for secretin was found in colonic liver metastases. Conclusions: VIP and secretin were both expressed on normal colon tissues. Binding of VIP decreased while secretin increased in colonic liver metastasis. A down-regulation of receptors for VIP in colonic liver metastases may helpful to understand the migration of colon cancer.Objective: To investigate the expression of the receptors for vasoactive intestinal peptide (VIP) and secretin in colon cancer. Methods: This study visualized and characterized the receptors for VIP and secretin in the sequence of human tumor-free colon, adenoma, carcinoma, liver metastasis using storage phosphor autoradiography. Results: Receptors for VIP and secretin were demonstrated in tumor-free colon and colon tumors. A decrease in affinity of VIP receptors was shown in the colonic liver metastasis (Kd = 3.30 nmol) when compared with tumor-free colon (Kd = 0.82 nmol). An up-regulation of receptors for secretin was found in colonic liver metastases. Conclusions: VIP and secretin were both expressed on normal colon tissues. Binding of VIP decreased while secretin increased in colonic liver metastasis. A down-regulation of receptors for VIP in colonic liver metastases may helpful to understand the migration of colon cancer.

关 键 词：Storage phosphor autoradiography Gut peptide receptor 

分 类 号：R730.2[医药卫生—肿瘤]