海洛因成瘾致大鼠脑损害的几种超微结构病理变化的鉴别  

THE IDENTIFICATION OF THE ULTRASTRUCTURAL CHANGES OF LESIONS WHICH HAVE BEEN MADE IN THE BRAINS OF THE HEROIN ADDICTED RATS

作　　者：韦献良[1] 韦力[1] 廖章鼎[1] 梁莹[2] 

机构地区：[1]广西医科大学解剖学教研室,南宁530021 [2]广西医科大学电镜室

出　　处：《广西医科大学学报》2009年第6期865-867,共3页Journal of Guangxi Medical University

基　　金：广西科学研究与技术开发计划项目(No.桂科攻0015050);广西教育厅科研项目(2003年)

摘　　要：目的:探讨海洛因成瘾致大鼠脑损伤的几种超微结构病理变化的鉴别及其意义。方法:建立海洛因成瘾大鼠模型,取模型大鼠多个脑区作电镜观察。结果:模型大鼠脑组织神经元出现变性、凋亡、胀亡等超微结构病理变化。星形胶质细胞出现肥大增生和退变。其中神经元胀亡与凋亡,神经元变性与胀亡早期,凋亡神经元与肥大星形胶质细胞表现相像,容易造成误判,要凭相应特征方可作鉴别。结论:对上述几种超微结构病理变化的鉴别,有助于研究海洛因成瘾致脑损害的病理、病程、治疗及预后。Objective:To study the identification of the ultrastructural changes of lesions which have been made in the brains of the heroin addicted rats.Methods:The rats were given of heroin and the addicted model was established.Some regions of model vatis brains were taken out and were observed under eletronic microscope.Results:Degeneration,apoptosis,oncosis were found in the heroin addicted rat brains.The hyperplasia and degeneration astrocytes were also found between the apoptosis and the oncosis of neuron, and ...

关 键 词：海洛因 成瘾 大鼠 脑 病理 超微结构 

分 类 号：R74[医药卫生—神经病学与精神病学]