高嘌呤食饵诱发雌性鹌鹑高尿酸血症模型病理特征的系统研究  

Systemic Study on Model Female Quail Pathological Characteristics of Hyperuricemia(HUA) Caused by High-purin Food

作　　者：杨红莲[1] 张冰[1] 刘小青[1] 林志健[1] 

机构地区：[1]陕西中医学院附属医院,咸阳712000

出　　处：《浙江中医药大学学报》2010年第6期816-818,共3页Journal of Zhejiang Chinese Medical University

基　　金：国家自然科学基金资助项目(No:30472282);北京市自然科学基金资助项目(No:7052036)~~

摘　　要：[目的]动态观察造模280d期间雌性鹌鹑高尿酸血症(HUA)模型的病理特征。[方法]选择迪法克品系雌性鹌鹑30只,按体重随机分为对照组和模型组,每组15只。高嘌呤食饵喂饲280d,定期检测血清尿酸(UA)、甘油三酯(TG)、血糖(GLU)、低密度脂蛋白(LDL)、总胆固醇(TC)等指标。并与对照组比较。[结果]高嘌呤食饵喂饲雌性鹌鹑280d期间,高UA水平持续稳定;随着造模时间延长,模型动物可伴发糖、脂代谢紊乱,并出现肝、肾功能损伤的病理表现。[结论]该方法制造的高尿酸血症模型稳定。[Objective] To dynamically observe pathological feature of female quail HUA.[Method] Select 30 quails;randomly divide them into control and model groups by weight,15 in each one.Take high-purin food for 280d,periodically measure UA,TG,GLU,LDL and TC,compare them between both groups.[Result] The UA level is stable continually;with modeling time passing,the model animals have pathological symptoms glucose and lipid metabolism,also injury of liver and kidney.[Conclusion] The method has stable model of hyperuricemia.

关 键 词：高嘌呤食饵 雌性鹌鹑 高尿酸血证模型 病理特征 

分 类 号：R361.2[医药卫生—病理学]