Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population  

作　　者：Ying Zeng  Nan-Nan Liu  Guang-Hui Dong  Jie Chen  Bin Wang Qing-Min Sun  Li Yang 

机构地区：[1]Key Laboratory of Reproductive Medicine Department of Pharmacology Nanjing Medical University Nanjing 210029 Jiangsu Province China [2]The Affiliated Wuxi Hospital for Maternal and Child Health Care of Nanjing Medical University Wuxi 214002 China [3]Department of General Surgery First Affiliated Hospital of Nanjing Medical University ,Nanjing 210029,Jiangsu Province,China

出　　处：《World Journal of Gastroenterology》2010年第28期3578-3583,共6页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China,No.30873099;Natural Science Foundation of Jiangsu Province,No.BK2006525;No.08KJB320004;"333 Project"and"Qinglan Project"Funds for the Young Academic Leader of Jiangsu Province to Wang B

摘　　要：AIM:To investigate the association between pre-miR- 146a C/G polymorphism and gastric cancer risk. METHODS:We performed a hospital-based,case-control study using polymerase chain reaction-restriction fragment length polymorphism method in 608 individuals(304 gastric cancer patients and 304 age and sex matched cancer-free controls).RESULTS:The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups(P=0.037).Compared with CC genotype carriers,subjects with the variant genotypes(GC+GG)had a 58%increased risk of gastric cancer(adjusted OR=1.58,95%CI:1.11-2.20,P= 0.009).Moreover,a higher gastric cancer risk was especially evident in younger individuals aged≤58 years, nonsmokers,and males(adjusted OR=1.76,95%CI: 1.08-2.87,P=0.024;adjusted OR=1.55,95%CI: 1.06-2.28,P=0.025;adjusted OR=1.53,95%CI: 1.04-2.27,P=0.033;respectively). CONCLUSION:Pre-miR-146a C/G polymorphism might be associated with an elevated risk of gastric cancer in Chinese population.AIM:To investigate the association between pre-miR- 146a C/G polymorphism and gastric cancer risk. METHODS:We performed a hospital-based,case-control study using polymerase chain reaction-restriction fragment length polymorphism method in 608 individuals(304 gastric cancer patients and 304 age and sex matched cancer-free controls).RESULTS:The frequencies of pre-miR-146a C/G genotypes in the case group were significantly different from those in the control groups(P=0.037).Compared with CC genotype carriers,subjects with the variant genotypes(GC+GG)had a 58%increased risk of gastric cancer(adjusted OR=1.58,95%CI:1.11-2.20,P= 0.009).Moreover,a higher gastric cancer risk was especially evident in younger individuals aged≤58 years, nonsmokers,and males(adjusted OR=1.76,95%CI: 1.08-2.87,P=0.024;adjusted OR=1.55,95%CI: 1.06-2.28,P=0.025;adjusted OR=1.53,95%CI: 1.04-2.27,P=0.033;respectively). CONCLUSION:Pre-miR-146a C/G polymorphism might be associated with an elevated risk of gastric cancer in Chinese population.

关 键 词：Pre-miR-146a MIR-146A Gastric cancer POLYMORPHISM GENOTYPE 

分 类 号：R735.2[医药卫生—肿瘤]