Obstructive sleep apnea syndrome and fatty liver: Association or causal link?  

作　　者：Mohamed H Ahmed Christopher D Byrne 

机构地区：[1]Chemical Pathology Department, Southampton University Hospital NHS Trust, Southampton, SO16 6YD, United Kingdom [2]Endocrinology and Metabolism, DOHaD Division, University of Southampton and Southampton University Hospitals Trust, Southampton, SO16 6YD, United Kingdom

出　　处：《World Journal of Gastroenterology》2010年第34期4243-4252,共10页世界胃肠病学杂志（英文版）

摘　　要：Obstructive sleep apnea (OSA) is a complex disorder that consists of upper airway obstruction, chronic intermittent hypoxia and sleep fragmentation. OSA is well known to be associated with hypoxia, insulin resistance and glucose intolerance, and these factors can occur in the presence or absence of obesity and metabolic syndrome. Although it is well established that insulin resistance, glucose intolerance and obesity occur frequently with non-alcoholic fatty liver disease (NAFLD), it is now becoming apparent that hypoxia might also be important in the development of NAFLD, and it is recognized that there is increased risk of NAFLD with OSA. This review discusses the association between OSA, NAFLD and cardiovascular disease, and describes the potential role of hypoxia in the development of NAFLD with OSA.Obstructive sleep apnea (OSA) is a complex disorder that consists of upper airway obstruction, chronic intermittent hypoxia and sleep fragmentation. OSA is well known to be associated with hypoxia, insulin resistance and glucose intolerance, and these factors can occur in the presence or absence of obesity and metabolic syndrome. Although it is well established that insulin resistance, glucose intolerance and obesity occur frequently with non-alcoholic fatty liver disease (NAFLD), it is now becoming apparen...

关 键 词：Sleep apnea syndrome HYPERLIPIDEMIA Non-alcoholic fatty liver disease Insulin resistance 

分 类 号：R766[医药卫生—耳鼻咽喉科]