Resistance of Helicobacter pylori to antibiotics from 2000 to 2009 in Shanghai  

作　　者：Qin-Juan Sun  Xiao Liang  Qing Zheng  Wei-Qi Gu  WenZhong Liu  Shu-Dong Xiao  Hong Lu 

机构地区：[1]Department of Gastroenterology,Shanghai Renji Hospital,Shanghai Institute of Digestive Disease,Shanghai Jiaotong University School of Medicine,Shanghai 200001,China

出　　处：《World Journal of Gastroenterology》2010年第40期5118-5121,共4页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China,No. 30770112;Shanghai Leading Academic Discipline Project, No. Y0205

摘　　要：AIM: To investigate the resistance of Helicobacter pylori (H. pylori ) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. METHODS: A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution. RESULTS: The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone.The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients. CONCLUSION: Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori -associated diseases.AIM: To investigate the resistance of Helicobacter pylori (H. pylori ) to 6 commonly used antibiotics from 2000 to 2009 in Shanghai. METHODS: A total of 293 H. pylori strains were collected from 2000 to 2009 in Shanghai and tested for their susceptibility to metronidazole, clarithromycin, amoxicillin, furazolidone, levofloxacin and tetracycline using agar dilution. RESULTS: The resistant rates of H. pylori to clarithromycin (8.6%, 9.0% and 20.7%) and levofloxacin (10.3%, 24.0% and 32.5%) increased from 2000 to 2009 in Shanghai. The resistant rate of H. pylori to metronidazole remained stable (40%-50%). Only one strain of H. pylori isolated in 2005 was resistant to tetracycline. All strains were sensitive to amoxicillin and furazolidone.The resistant rate of H. pylori to antibiotics was not related with the sex, age and clinical outcome of patients. CONCLUSION: Resistance of H. pylori to antibiotics plays an important role in making treatment strategies against H. pylori -associated diseases.

关 键 词：Helicobacter pylori Antibiotic resistance Agar dilution METRONIDAZOLE CLARITHROMYCIN LEVOFLOXACIN Tetracycline AMOXICILLIN FURAZOLIDONE 

分 类 号：R57[医药卫生—消化系统]