肌萎缩侧索硬化症患者抑郁状况调查及药物干预效果  

Investigation on depression of patients with amyotrophic lateral sclerosis and effect with drug treatment

作　　者：郁可[1] 王庆松[1] 李从阳[1] 王俊[1] 向阳[1] 

机构地区：[1]成都军区总医院神经内科,成都610083

出　　处：《脑与神经疾病杂志》2011年第1期48-50,共3页Journal of Brain and Nervous Diseases

摘　　要：目的调查肌萎缩侧索硬化症(ALS)患者抑郁发生率并观察药物干预效果。方法采用汉密尔顿抑郁量表(HAMD)对64例ALS患者进行测评,对伴有抑郁的不同性别、年龄及文化程度的患者进行评分比较,并对其中30例患者行抗抑郁药物干预,1个月后再进行量表测定。结果 64例ALS患者中有60例(93.4%)存在不同程度的抑郁,不同性别及年龄组的ALS患者HAMD得分无显著差异(P>0.05),但文化程度较高的ALS患者抑郁程度显著高于文化程度较低的ALS患者(P<0.01),30例伴有抑郁的ALS患者在接受抗抑郁药物干预1个月后其抑郁程度明显减轻(P<0.01)。结论绝大多数ALS患者合并抑郁,合理药物干预能有效改善ALS患者的抑郁状态。Objective To study the incidence of depression in amyotrophic lateral sclerosis(ALS) and the effect with drug intervention.Methods 64 ALS patients were evaluated by Hamilton depression scale(HAMD)and the cases who accompanied by depression were compared with the scores of different sex,age and educational level.The 30 cases were scored with HAMD and compared before and 1 months after the treatment.Results The depression was found 60 of 64(93.4%)patients with ALS.There was significant difference in HAMD scor...

关 键 词：肌萎缩侧索硬化症 抑郁 汉密尔顿 帕罗西汀 

分 类 号：R744[医药卫生—神经病学与精神病学]