脑深部电刺激治疗异动症模型大鼠的行为学研究  

The behavior research of rat model of Levodopa-induced dyskinesia with deep brain stimulation

作　　者：浦政[1] 陆丽霞[1] 刘振国[1] 

机构地区：[1]上海交通大学医学院附属新华医院神经内科,上海200092

出　　处：《脑与神经疾病杂志》2011年第1期6-10,共5页Journal of Brain and Nervous Diseases

基　　金：上海市科委纳米专项基金(0952nm03700);上海市基础研究重点项目(09JC1411000);上海市教育委员会科研创新重点项目(10ZZ72);上海市白玉兰科技人才基金项目(1009B097)

摘　　要：目的观察高频电刺激对帕金森病异动症大鼠模型的行为学影响。方法成功制备帕金森病、异动症和丘脑底核高频电刺激大鼠模型,随机分为"刺激组"、"假刺激组"和"假手术组",观察高频电刺激对旋转行为和不自主行为(AIM)评分的影响。结果高频电刺激可抑制模型大鼠的旋转行为;在左旋多巴甲酯和苄丝肼药效期内高频电刺激治疗后的"刺激组"模型大鼠AIM评分明显减低、旋转速度明显减慢。结论高频电刺激可改善左旋多巴诱导的异动症(LID)的症状;其作用并非刺激电极植入本身对丘脑底核(STN)损伤所致;STN-DBS治疗后LID症状可在一定时间内持续改善。Objective To observe the change of behavior of the rat models of Levodopa-induced dyskinesia with subthalamus nucleus deep brain stimulation.Methods The rat models of Parkinson s Disease,Levodopa-induced dyskinesia and subthalamus nucleus deep brain stimulation were successfully set up.The groups of "stmulation","sham stimulation" and "sham plantation" were divided randomly,with each group was given corresponding stimulation test.The speed of rotation and score of AIM were compared.Results The speed of rota...

关 键 词：异动症 脑深部电刺激 丘脑底核 行为学研究 

分 类 号：R742.5[医药卫生—神经病学与精神病学]