乳腺癌保乳术后常规、三维适形和直接子野优化调强放疗技术剂量学评估  

Dosimetric Evaluation of CR,3D-CRT and DMPO-IMRT for Breast Cancer After Conservative Surgery

作　　者：张富利[1] 王平[1] 郑明民[1] 

机构地区：[1]北京军区总医院放疗科,北京100700

出　　处：《中国医学物理学杂志》2011年第2期2491-2494,2540,共5页Chinese Journal of Medical Physics

摘　　要：目的:比较乳腺癌保乳术后常规放疗(CR)、三维适形(3D-CRT)放疗、直接子野优化调强适形(DMPO-IMRT)放疗靶区剂量分布及危及器官受照体积等方面的差异。方法:随机选择10位乳腺癌患者,为每位患者设计上述三种照射技术的治疗计划。处方剂量为50 Gy/2 Gy/25次。所有计划都使95%靶区体积达到处方剂量要求。根据积分剂量体积直方图(DVH)比较靶区受量和相关正常器官受量的差异和剂量分布。结果:三种技术靶区均匀性指数(HI)和适形度指数(CI)差异均有显著性意义(P=0.049,P=0.001),其中尤以DMPO-IMRT的指标最佳。与CR相比,3DCRT降低了患侧肺、对侧乳腺和心脏在各个剂量区的受照体积,而DMPO-IMRT增大了患侧肺(V20、V30除外)、对侧乳腺和心脏的受照体积。与3DCRT相比,DMPO-IMRT增大了患侧肺(V30除外)、对侧乳腺和心脏的受照体积。结论:与CR相比,3D-CRT和DMPO-IMRT改善了靶区的均匀性和适形度。与此同时,3DCRT降低了本研究中各个剂量区危及器官的受照体积,DMPO-IMRT在降低患侧肺高剂量受照体积的同时,增大了患侧肺、对侧乳腺、心脏的低剂量受照体积。Objective: To compare the dose distribution and volume histogram(DVH) of the planning target volume(PTV) and organs at risk(OAR) between conventional radiation therapy(CR),three-dimensional conformal radiation therapy(3D-CRT) and direct machine parameter optimization intensity-modulated radiation therapy(DMPO-IMRT) after breast-conserving surgery.Methods: For each of 10 randomly chosen patients,3 plans were designed for 3 irradiation techniques.The prescribed dose was 50 Gy/2 Gy/25 f,95% of the planning tar...

关 键 词：乳腺癌 常规切线照射 三维适形放疗 直接子野优化调强适形放疗 

分 类 号：R737.9[医药卫生—肿瘤]