实验性变态反应性脑脊髓炎大鼠穹窿下器的水肿观察  

Study of the edema on the subfornical organ in experimental allergic encephalomyelitis rats

作　　者：叶建亚[1] 马常升[2] 曹翠丽[2] 李聪慧[3] 

机构地区：[1]河北医科大学西山校区,河北050200 [2]河北医科大学 [3]石家庄市第一医院

出　　处：《脑与神经疾病杂志》2011年第2期89-92,共4页Journal of Brain and Nervous Diseases

基　　金：河北省自然科学基金项目(302491)

摘　　要：目的观察实验性变态反应性脑脊髓炎(EAE)大鼠不同时期穹窿下器(SFO)的水肿变化。方法建立大鼠EAE模型,分别用光镜和透射电镜观察EAE不同时期SFO的水肿改变。结果随病情进展,SFO的水肿逐渐加重,病情缓解后,水肿减轻。潜伏期至发病极期水肿主要局限在血管周围,恢复期水肿呈现弥散性。结论 SFO在EAE不同时期发生的水肿改变与临床进展呈一致性,参与了脑的免疫调节。Objective To observe the edema on the subfornical organ(SFO) of rats in different periods of experimental allergic encephalomyelitis(EAE).Methods Animals were actively immunized to induce EAE.Then their subfornical organs were taken out to be observed by HE stainins and transmission electron microscope respectively.Results Edema of SFO aggravated following progress and relieved with alleviation of EAE.The edema limited to perivascular region from the latent period to the summit and diffused during the resto...

关 键 词：实验性变态反应性脑脊髓炎 穹窿下器 水肿 大鼠 

分 类 号：R744.3[医药卫生—神经病学与精神病学]