Guillain-Barré综合征患者B淋巴细胞辅助受体CD l9表达的研究  

Expression of CO-receptor CD 19 on peripheral B lymphocytes in patients with Guillain-Barre syndrome

作　　者：袁学谦[1] 朱太卿[1] 张莉峰 王慧贞[1] 王焕荣[1] 王爱丽[1] 张东锋[1] 

机构地区：[1]郑州人民医院神经内科,河南450003

出　　处：《脑与神经疾病杂志》2011年第3期231-233,共3页Journal of Brain and Nervous Diseases

摘　　要：目的本研究通过检测Guillain-Barre综合征(GBS)患者外周血单个核细胞CD l9蛋白的表达,探讨CD l9与GBS及其严重程度之间的关系。方法利用流式细胞术检测GBS组(36例)和正常对照组(20例)的CD l9蛋白表达,按病程将GBS组分为急性期亚组与恢复期亚组,并分析与疾病严重程度之间的关系。结果与正常对照组221±78个比较,GBS组742±128个B细胞数量显著升高,差异有统计学意义(P<0.01)。与正常对照组62.21±7.85%比较,GBS组83.92±6.23%CD l9+CD20+显著升高,差异有统计学意义(P<0.01)。与恢复期GBS组686±108个比较,急性期GBS组810±124个B细胞数量无明显差异(P>0.05)。与恢复期GBS组87.27±6.04%比较,急性期GBS组81.20+5.25%CD l9+CD20+无明显差异(P>0.05)。与轻症GBS组632+68个比较,重症GBS组797+130个B细胞数量无明显差异(P>0.05)。与轻症GBS组82.53+5.03%比较,重症GBS组85.84+6.77%CD l9+CD20+无明显差异(P>0.05)。结论 CD l9在GBS中表达显著升高,但与病程和病情严重程度无关。Objective To explore the corlation between the expression of CD19 and the severity of GBS.The expression of CD19 of B lymphocyte in peripheral blood mononuclear cells(PBMNCs)of the disease was tested.Methods GBS group(36 cases)and healthy controls(HC)group(20 cases)were investigated.The expression of CD 19 on peirpheral B lymphocytes were examined by flow cytometry.According to course of disease,GBS group was divided into acute subgroup and recovery subgroup.Furthermore,the corelation between the expression...

关 键 词：CD l9 GUILLAIN-BARRÉ综合征 流式细细胞术 

分 类 号：R745.43[医药卫生—神经病学与精神病学]