平行人造膜通透性测定方法(PAMPA)在吸收研究中的应用  

The application of parallel artificial membrane permeability assay(PAMPA)in the research of drug absorption

作　　者：李楠[1,2] 叶英杰[1] 杨明[3] 蒋学华[2] 

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地,四川成都610075 [2]四川大学华西药学院,四川成都610041 [3]江西中医学院中药现代制剂教育部重点实验室,江西南昌330004

出　　处：《中药与临床》2011年第1期28-30,共3页Pharmacy and Clinics of Chinese Materia Medica

摘　　要：本文依据近年来国内外相关文献资料,对有关PAMPA细胞模型自身及应用的发展进行了综述。介绍了平行人造膜通透性测定法(PAMPA)自身及其在药物吸收方面应用的热点和最新进展。通过文献研究发现PAMPA细胞模型不断优化与改良,近年来主要应用于化合物高通量筛选、处方设计等方面。而将PAMPA模型应用于国内药物吸收研究值得关注。In this study,the parallel artificial membrane permeability assay(PAMPA) and the development of its application in absorption are introduced according to the pertinent literature.The PAMPA method and its advancement are discussed.After carefully investigated,the PAMPA method is found to be optimized continuously.In recent years,the PAMPA method has mainly been used in the aspects of high-flux screening and performulaion.It would be worthy to pay attention to the absorption study in domestic research.

关 键 词：平行人造膜通透性测定法 吸收 进展 

分 类 号：R[医药卫生]