G蛋白耦连受体激酶在帕金森病发病机制中的研究进展  

Research progress of G protein-coupled receptor kinases in pathogenesis of Parkinson's disease

作　　者：吴娜[1] 刘振国[1] 

机构地区：[1]上海交通大学医学院附属新华医院神经内科,上海200092

出　　处：《上海交通大学学报（医学版）》2011年第8期1194-1197,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市科委基金(0952nm03700;09JC1411000);上海市教委基金(10ZZ72);上海市白玉兰科技人才基金(1009B097);国家自然科学基金(81071025)~~

摘　　要：G蛋白耦连受体激酶(GRKs)是一类介导受体脱敏的重要可溶性蛋白质,是G蛋白耦连受体(GPCR s)信号转导通路负反馈机制中必不可少的因素。神经系统疾病中神经激素水平的升高,以及神经激素持续刺激引起的不利后果,表明了神经激素受体反应性脱敏是一种非常重要的保护机制。近年来研究显示,GRKs在帕金森病及其运动并发症的发展过程中起着重要作用,其中GRK6主要定位于中型棘状神经元上,GRK6敲除与多巴胺受体的超敏有关,是纹状体最关键的GRKs。文章就近年来GRKs在帕金森病发病机制中的研究进展进行综述。G protein-coupled receptor kinases(GRKs) are a class of important soluble proteins that mediate receptor desensitization.They are the essential elements in negative feedback mechanism of G protein-coupled receptors(GPCRs) signaling pathway.Increased neurohormonal levels in nervous system diseases and adverse consequences in nervous system diseases induced by sustained neurohormonal stimulation indicate that the desensitization of neural receptors is a very important protection mechanism.Recent researches have revealed that GRKs play an important role in the development of Parkinson's disease and its motor complications.GRK6,which is localized in medium-sized spinous neurons,is the most critical GRKs in striatum.GRK6 knockout is related to the hypersensitivity of dopamine receptor.The research progress of GRKs in the pathogenesis of Parkinson's disease is reviewed in this paper.

关 键 词：帕金森病 G蛋白耦连受体激酶 G蛋白耦连受体 

分 类 号：R742.5[医药卫生—神经病学与精神病学]