Hamartin和tuberin在86例肾血管平滑肌脂肪瘤中的表达  

Expression of hamartin and tuberin in 86 cases of angiomyolipoma of kidney

作　　者：王兆亮[1] 陈以明[1] 朱建善[1] 

机构地区：[1]上海交通大学医学院附属仁济医院病理科,上海200127

出　　处：《上海交通大学学报（医学版）》2011年第10期1428-1431,共4页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：目的探讨hamartin和tuberin蛋白在肾血管平滑肌脂肪瘤中的表达及意义。方法采用免疫组织化学EnVision二步法检测43例正常肾组织和86例肾血管平滑肌脂肪瘤组织中上述标志物的表达情况。结果 43例正常肾组织中hamartin和tuberin均阳性;在86例肾血管平滑肌脂肪瘤中hamartin的阳性表达率为81.25%,tuberin的阳性表达率为93.75%。结论 Hamartin和tuberin蛋白的失表达可能与部分肾血管平滑肌脂肪瘤的发生有关,散发的肾血管平滑肌脂肪瘤的发病机制可能与结节性硬化综合征相关型有所不同。Objective To investigate the expression and significance of hamartin and tuberin protein in angiomyolipoma of the kidney. MethodsThe expression of the above biomarkers was detected in 43 cases of normal renal tissues and 86 cases of angiomyolipoma of the kidney by immunochemical EnVision method. ResultsThere was positive expression of hamartin and tuberin protein in all the 43 cases of normal renal tissues.While in 86 cases of angiomyolipoma of the kidney,the positive expression rate of hamartin was 81.25%,and that of tuberin was 93.75%. ConclusionLoss of expression of hamartin and tuberin protein may be associated with the occurrence of some cases of angiomyolipoma of the kidney,and the pathogenesis of sporadic angiomyolipoma of the kidney may be different from that of tuberous sclerosis complex(TSC)-associated type.

关 键 词：肾脏肿瘤 血管平滑肌脂肪瘤 免疫组织化学 HAMARTIN TUBERIN 

分 类 号：R737.11[医药卫生—肿瘤]