MicroRNA与膀胱癌的研究进展  

Advance in research between MicroRNA and bladder cancer

作　　者：蒋海锋[1] 薄隽杰[1] 

机构地区：[1]上海交通大学医学院附属仁济医院泌尿外科,上海200127

出　　处：《中国癌症杂志》2011年第4期308-312,共5页China Oncology

基　　金：上海市科委自然基金资助项目(No:09ZR14180000)

摘　　要：微小RNA(MicroRNA,miRNA)是一类小分子RNA,在转录后水平对基因的表达进行调控。目前研究证明,miRNA可通过不同信号通路直接参与人类多种肿瘤的形成与发展。本文就miRNA的形成、作用机制及其与肿瘤的关系等方面予以综述,并着重介绍了miRNA在膀胱癌中的研究进展。microRNAs(miRNAs) are a class of small RNA molecules that regulate gene expression at the post-transcriptional level.Current studies have shown that miRNAs,which act as oncogenes or tumor suppressors,are directly involved in the formation and development of many kinds of human tumors.The aim of this review was to describe the formation and mechanism of miRNA,its relationship with cancer and also summarize the advances about the role of miRNA in bladder cancer.

关 键 词：MICRORNA 膀胱癌 肿瘤 

分 类 号：R73[医药卫生—肿瘤]