肺癌组织中含十字形结构域蛋白3表达的意义  

The Expression of Jumonji Domain-Containing Protein 3 in Lung Cancer Tissue

作　　者：胡贺芳[1] 时辉[1] 车国卫[1] 罗凤鸣[1] 

机构地区：[1]四川大学华西医院,四川成都610041

出　　处：《中国呼吸与危重监护杂志》2011年第2期168-170,共3页Chinese Journal of Respiratory and Critical Care Medicine

基　　金：国家自然科学基金(编号:30500222;30871118;30971325)

摘　　要：目的研究含十字形结构域蛋白3(JMJD3)在肺癌组织中的表达。方法 53例手术证实的不同病理分期肺癌患者用免疫组化检测肺癌组织JMJD3表达情况,随访患者生存时间,分析JMJD3与患者组织类型、TNM分期以及生存时间的关系。结果 94.3%的患者肺癌组织不同程度表达JMJD3。JMJD3表达与TNM分期呈显著负相关(r=-0.347,P=0.002),JMJD3低表达的患者生存时间明显短于高表达患者(2=17.83,P=0.001)。JMJD3表达与肺癌的组织类型与分化程度相关不明显。结论 JMJD3表达降低可能促进肺癌的发生发展。Objective To investigate the expression of Jumonji domain-containing protein 3(JMJD3) in lung cancer tissue.Methods The cancer tissue slides from 53 lung cancer patients with different TNM stages were immunostained with JMJD3 antibody.The relationship between the expression of JMJD3 and type of pathology,TNM stage,survival time was analyzed.Results 94.3% lung cancer tissue expressed JMJD3 protein.The expression of JMJD3 was negatively correlated with TNM stage(r=-0.347,P=0.002).The patients with decreased JMJD3 expression had shorter survival time than the patients with high JMJD3 expression(X2=17.83,P=0.001).Conclusion Decreased expression of JMJD3 may promote the lung cancer progression.

关 键 词：肺癌 含十字形结构域蛋白3 肿瘤分期 生存分析 

分 类 号：R734.2[医药卫生—肿瘤]