醛缩酶A在肠易激综合征患者结肠黏膜的表达  

The expression of aldolase A in colonic mucosa from the IBS

作　　者：张春燕[1] 杨云生[2] 郭旭[2] 孙刚[2] 王巍峰[2] 

机构地区：[1]海军总医院干部综合科,北京100048 [2]解放军总医院消化病中心

出　　处：《中华临床医师杂志（电子版）》2011年第12期3513-3517,共5页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金资助项目(30570822)

摘　　要：目的研究醛缩酶A(ALDOA)在肠易激综合征(IBS)患者结肠黏膜的表达情况,探讨IBS发病的新机制,为未来研究提供新的思路。方法应用Western blot和免疫组织化学等方法,观察ALDOA在腹泻型肠易激综合征(IBS-D)及便秘型肠易激综合征(IBS-C)患者结肠黏膜的表达情况。结果 ALDOA在IBS-D组乙状结肠、IBS-C组乙状结肠及IBS-D组盲肠表达量明显少于健康对照组的相应部位,差异有统计学意义。结论 ALDOA在IBS患者结肠的表达异常提示着IBS-D、IBS-C患者结肠存在能量代谢异常。Objective The expression of aldolase A(ALDOA)was detected in colonic mucosa from the IBS with diarrea(IBS-D) group,IBS with constipation(IBS-C) group and normal control group.All these researchs may provide new clues to further research on the molecular mechisms of IBS.Methods Western blot and IHC were also performed for observing the level of ALDOA.Results The results showed that ALDOA were markedly decreased in mucosa of cecum and sigmoid colon from IBS-D and IBS-C groups than that of normal controls.Conclusions ALDOA were metabolism enzymes.The abnormal expression of ALDOA showed that colonic mucosa from IBS patients may involve in dysregulation of energy metabolism.

关 键 词：肠易激综合征 果糖-二磷酸醛缩酶 肠黏膜 

分 类 号：R574[医药卫生—消化系统]