人脑星形细胞瘤中Wiskott-Aldrich综合征蛋白质与T淋巴瘤侵袭转移诱导因子1蛋白表达的意义  

Possible role of WASP and Tiam1 proteins in progression of astrocytomas

作　　者：侯景辉[1,2] 曾敬[1,2] 卢佳斌[1,2] 吴惠瑜 符珈[1,2] 吴秋良[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室,广州510060 [2]中山大学肿瘤防治中心病理科 [3]中山大学肿瘤防治中心综合科

出　　处：《中华临床医师杂志（电子版）》2011年第12期3528-3531,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：广东省医学科研基金(B2008223)

摘　　要：目的探讨不同病理学级别人脑星形细胞瘤中Rho GTPases相关信号通路蛋白Wis-kott-Aldrich综合征蛋白质(WASP)与T淋巴瘤侵袭转移诱导因子1(Tiam1)所扮演的可能角色。方法应用免疫组织化学法检测60例不同病理级别人脑星形细胞瘤组织中WASP、Tiam1蛋白表达,评估其与星形细胞瘤的病理分级及临床特征的关系。结果 (1)Tiam1蛋白高级别组的阳性率和高表达率均高于瘤旁脑组织和低级别组(P<0.05),且Tiam1蛋白的阳性率和高表达率有从瘤旁脑组织→低级别星形细胞瘤→高级别星形细胞瘤递增的趋势,Tiam1表达的强弱在一定程度上反映了人脑星形细胞瘤的恶性程度。(2)Tiam1蛋白表达的阳性率和高表达率与年龄、性别、部位及肿瘤最大径无关(P>0.05)。(3)WASP蛋白为阴性表达。结论 WASP蛋白与星形细胞瘤发生和进展的相关性不明确;Tiam1蛋白在了解星形细胞瘤恶性进展方面有参考价值,且可能是有预后价值因子之一。Objective To explore the role of WASP and Tiam1 proteins in progression of astrocytomas.Methods We Examined the expression of WASP and Tiam1 proteins by immmunohistochemical methods,and to analysis the correlation of WASP and Tiam1 expression with clinicopathological factors in the 60 patients with astrocytomas.Results(1)The positivity rate and overexpression rate of Tiam1 protein were significantly higher in the high-grade astrocytomas group than in the low-grade astrocytomas group or the brain tissues around tumor group(P<0.05).From the brain tissues around tumor,the low-grade astrocytomas to the high-grade astrocytomas,the positivity rate and overexpression rate of Tiam1 protein were gradually increased.(2)The positivity rate and overexpression rate of Tiam1 protein were correlated with histological grade(P<0.05),but not with sex,age,site and the maximal diameter of tumors(P>0.05).(3)WASP protein expression was negative in each group.Conclusions WASP probably is not correlated with the carcinogenesis and progression in astrocytomas.Tiam1 may serve as a parameter for evaluating the carcinogenesis and progression in astrocytomas,and work as a prognostic factor for astrocytomas patients.

关 键 词：Wiskott-Aldrich综合征蛋白质 星形细胞瘤 T淋巴瘤侵袭转移诱导因子1 

分 类 号：R739.4[医药卫生—肿瘤]