NF-κB与蛋白激酶CβⅡ在胃癌中的表达及意义  

Expression and significance of NF-κB and PKCβⅡ receptor in gastric carcinoma

作　　者：朱莉 邹赛英[2] 唐新萍[2] 张培谊[2] 赵海华[2] 马莉[2] 

机构地区：[1]新疆医科大学基础医学院,乌鲁木齐830011 [2]兰州军区乌鲁木齐总医院病理科

出　　处：《中华临床医师杂志（电子版）》2011年第15期4340-4344,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的检测143例胃癌组织中NF-κB和PKCβⅡ的表达情况,探讨二者在胃癌组织中表达的相关性,以及与胃癌临床病理的关系。方法采用免疫组化(SP)法,检测143例手术切除胃癌及癌旁正常胃组织中NF-κB、PKCβⅡ的表达情况,并与临床病理特征结合进行综合分析。结果 NF-κB在胃癌组织中表达率(67.1%)高于癌旁正常组织(21.6%),二者之间差异具有统计学意义(P<0.05);PKCβⅡ胃癌组织中表达率(58.4%)高于癌旁正常组织(30.8%),二者之间差异具有统计学意义(P<0.05);二者表达呈正相关,与胃癌的组织学类型、浸润深度及淋巴结转移具有相关性。结论 NF-κB与PKCβⅡ在胃癌组织中高表达,并且与胃癌的发生、恶性程度、浸润深度、淋巴结转移和TNM分期有一定的关系,二者在胃癌的发生发展中可能具有协同作用。联合检测两种指标有望对胃癌发生发展的研究、判断预后及靶向治疗提供依据。Objective To detect the expression of NF-κB and PKCβⅡin gastric carcinoma,discuss their correlation in gastric carcinoma tissues and the relationship with clinicopathological parameters.Methods The expression of NF-κB and PKCβⅡwas examined in 143 cases of gastric carcinoma and normal gastric mucosa tissue with immunohistochemical technique.The datum were analyzed with χ2 tests.Results The expression rate of NF-κB in carcinoma tissues was 67.1%,which was significantly higher than that in normal tissues(21.6%,P<0.05).The expression rate of PKCβ Ⅱ in carcinoma tissues was 58.4%,which was significantly higher than that in normal tissues(30.8%,P<0.05).Both of them were positively related to the histological type,depth of tumor invasion and lymph node metastasis.Conclusions NF-κB and PKCβⅡ are overexpressed in gastric carcinoma and related to the histological type,depth of tumor invasion,lymph node and TNM stage.Both of them may cooperate with the development and progression of gastric carcinoma.Joint detection of the two types of indicators may play an important role in studying the development and progression,prognosis and targeted therapy of gastric carcinoma.

关 键 词：胃肿瘤 NF-ΚB 蛋白激酶C 

分 类 号：R735.2[医药卫生—肿瘤]