单胺氧化酶A串联重复序列多态性与酒精依赖行为关系的Meta分析研究  

Association of MAOA-VNTR with alcoholism:meta analysis

作　　者：禚振华[1] 姚树桥[1] 

机构地区：[1]中南大学湘雅二医院医学心理学研究所,长沙410011

出　　处：《中华临床医师杂志（电子版）》2011年第16期4770-4773,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家科技支撑计划课题(2009BAI77B02)

摘　　要：目的探讨酒精依赖行为与单胺氧化酶A串联重复序列多态性(MAOA-VNTR)的关系。方法通过EMBASE、Sciencedirect、PubMed、Googlescholar、CNKI收集1990～2010年公开发表的关于酒精依赖行为与MAOA-VNTR相关性的病例对照研究,利用元分析软件(CMA)进行分析,通过计算合并优势比(OR值)进行比较。结果通过筛选,共有10篇文献(共3831例受试,其中对照组2084例,酒精依赖组1747例)符合我们的纳入标准。结果显示MAOA-VNTR多态性与酒精依赖行为之间关联不显著(OR=1.112,P=0.32),在亚组分析中MAOA-VNTR多态性与反社会酒精依赖亚型关联显著(OR=2.04,P<0.05)。结论 MAOA-VNTR多态性可能是反社会酒精依赖亚型的危险因子,而非酒精依赖行为的危险因子。Objective To explore the relationship between MAOA-VNTR and alcoholism.Methods We performed a meta-analysis of studies of the association between MAOA-VNTR and the alcoholism.The articles were identified from EMBASE,Sciencedirect,PubMed,Googlescholar and CNKI from 1990 to 2010.Results A random-effects model was used to combine results from ten case-control studies.The association is significant in antisocial alcoholics(OR=2.04,P<0.05),not in alcoholics(OR=1.112,P=0.32).Conclusions MAOA-VNTR might be a risk factor for antisocial alcoholics,not for alcoholics.

关 键 词：反社会性人格障碍 酒精中毒 META分析 单胺氧化酶A串联重复序列多态性 

分 类 号：R749.6[医药卫生—神经病学与精神病学]