代谢综合征诊断指标与前列腺特异性抗原相关性研究  

Relationship study of components of metabolic syndrome and serum prostate-specific antigen levels

作　　者：张辉[1] 王玉秋[1] 袁晓东[1] 丁森泰[1] 李子尧[2] 吕家驹[1] 

机构地区：[1]山东大学附属省立医院泌尿外科,济南250021 [2]山东省疾病预防控制中心

出　　处：《中华临床医师杂志（电子版）》2011年第21期6285-6290,共6页Chinese Journal of Clinicians(Electronic Edition)

基　　金：山东省科学技术发展计划项目(2008GG30002009)

摘　　要：目的探讨代谢综合征(MS)诊断指标对前列腺特异性抗原(PSA)水平的影响。方法选择20～79岁健康查体男性4833例,分别测量其血压、身高、体重,计算体重指数(BMI),检测空腹状态下生化指标[血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL)、高低密度脂蛋白胆固醇(HDL)]及血清PSA;按NCEPATPⅢ和中华医学会糖尿病学分会的诊断标准定义代谢综合征。结果本样本中MS1060例(21.9%),样本人群PSA水平随着MS各诊断指标阳性数量的增加而逐渐降低(P=0.008)。在MS各诊断指标中,肥胖者和TG升高者中血清PSA水平较非肥胖者和非TG升高者明显降低(P均<0.01);高血压者中血清PSA水平则较血压正常者明显升高(P=0.001)。血清PSA水平与年龄(r=0.239,P<0.001)、收缩压(r=0.085,P<0.001)和TC(r=0.033,P=0.010)呈正相关,与BMI(r=-0.061,P<0.001)、FBG(r=-0.030,P=0.019)和TG(r=-0.043,P=0.001)呈负相关;而与舒张压(r=-0.009,P=0.257)、HDL(r=-0.017,P=0.118)无相关性。MS组中BMI、收缩压、舒张压、FBG、TG、TC等指标均显著高于非MS组(P均<0.05),而HDL及PSA水平则明显降低(P均<0.01)。结论 MS与低PSA水平呈现相关性,血清PSA水平受到年龄、MS诊断指标(肥胖、收缩压、FBG、TG和TC)的影响。Objective To investigate the relationship between components of metabolic syndrome (MS) and serum prostate-specific antigen levels.Methods In 4833 males aged 20-79 years,the blood pressure,height and body weight were measured,and body mass index (BMI) was calculated.The biochemical analyses of the fasting blood glucose(FBG),triglyceride (TG),high-density lipoprotein (HDL),total cholesterol (TC),low-density lipoprotein (LDL) and serum PSA were performed in the overnight-fasting state.MS was defined according to the definition of NCEP ATP Ⅲ and CDS.Results The incidence of MS in the study population was 21.9% (1060 of 4833).Serum PSA levels decreased gradually with the increasing MS components(P=0.008).Among MS components,Serum PSA levels in men with obesity and high TG were lower than men without (all P<0.01),while Serum PSA levels in men with hypertension were higher than without (P=0.001).Serum PSA levels were positively correlated with age(r=0.239,P<0.001),systolic BP (r=0.085,P<0.001) and TC(r=0.033,P=0.010),and were inversely correlated with BMI(r=-0.061,P<0.001),FBG(r=-0.030,P=0.019) and TG(r=-0.043,P=0.001).However,the association between PSA levels and diastolic BP (r=-0.009,P=0.257),HDL(r=-0.017,P=0.11) were not statistically significant.BMI,FBG,systolic BP,diastolic BP,TC and TG of men with MS were significantly higher than those without MS(all P<0.05),while the HDL and PSA levels of men with MS were significantly lower than those without MS (all P<0.01).Conclusions MS is associated with decreased serum PSA levels.The serum PSA level is significantly influenced by age and some components of MS (obesity,systolic BP,FBG,TG and TC).

关 键 词：前列腺特异抗原 代谢综合征X 

分 类 号：R737.25[医药卫生—肿瘤]