复方樟柳碱治疗原发性开角型青光眼疗效的临床研究  

Therapeutic effect of compound anisodine for primary open angle glaucoma

作　　者：陈艳虹[1] 吴联群[1] 

机构地区：[1]浙江大学医学院附属第一医院眼科,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2011年第6期659-662,共4页Journal of Zhejiang University(Medical Sciences)

基　　金：浙江省中医药局科研基金项目(200709145)

摘　　要：目的:评价复方樟柳碱(compound anisodine,CA)对眼压已控制的原发性开角型青光眼患者视神经的作用。方法:根据改良的HPA国际视野分期法,收集中期原发性开角型青光眼患者46例,随机分为CA组23例和对照组23例,分别接受复方樟柳碱颞浅动脉旁注射和维脑路通片口服治疗,比较治疗前后视力、眼压、眼底、视野及视乳头血流情况。结果:CA组视野平均缺损值(mean of defect,MD)明显改善;两组眼动脉收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV),视网膜中央动脉PSV、EDV、阻力指数(RI)较治疗前均有显著改善(P<0.05),且CA组改善程度优于对照组。结论:复方樟柳碱能有效改善原发性开角型青光眼患者的视功能和视乳头血流,保护视神经。Objective: To evaluate the therapeutic effect of compound anisodine(CA) for patients with primary open angle glaucoma(POAG). Methods: According to the modified Hodapp-Parrish-Anderson Visual Fields Grading System,46 patients with moderate stage POAG were randomized to receive compound anisodine injection(CA group) or venoruton tablets(control group).Visual acuity(VA),IOP,fundus,visual fields(VF) and the blood flow of optic nerve were observed. Results: The mean of defect(MD) was decreased in CA group after treatment.The PSV and EDV of ophthalmic artery were remarkably improved in both groups,as well as the PSV,EDV and RI of retinal central artery.Compound anisodine was superior in improving hemodynamics of ophthalmic artery and retinal central artery to venoruton. Conclusion: Compound anisodine can protect optic nerve of POAG through improving the visual function and blood supply of optic nerve.

关 键 词：青光眼 开角型/药物疗法 樟柳碱/治疗应用 原发性开角型青光眼 视功能 血流动力学 复方樟柳碱 

分 类 号：R775.4[医药卫生—眼科]