钠电流对皮层中间神经元放电模式影响  

Na+ Current to Extend the Influence of Firing Patterns in Interneurons

作　　者：周青青[1] 熊冬生[1] 刘深泉[2] 汪雷[2] 

机构地区：[1]华南理工大学生物医学工程系,广东广州510006 [2]华南理工大学数学系,广东广州510640

出　　处：《中国医学物理学杂志》2011年第6期3045-3050,共6页Chinese Journal of Medical Physics

基　　金：国家自然科学基金项目(No.10872069)

摘　　要：目的:通过分析FS模型来探索皮层抑制性中间神经元放电的规律。方法:数值分析钠离子通道参数改变的情况下,皮层中间神经元的发放模式以及不同发放模式之间的转移,并通过峰峰间距(InterSpike Intervals,ISIs)序列展示了不同发放模式转移过程中出现的各种周期分岔现象。结果与结论:随着钠通道参数的改变,出现了明显的倍周期分岔和逆倍周期分岔现象,并且最终发放模型从分岔模式回归到周期1簇的放电模式。从钠通道门变量m的三维分岔图得出,随着gd的增加,不同分岔图之间出现相似性,具有延缓特性。Objective: The firing patterns of inhibitory Interneurons in the neocortex are researched in this paper.Methods:Through FS mode,the numerical analysis on the firing patterns of among inhibitory neurons in the neocortex as well as the transformation among the patterns was made according to the change of parameters in Na ion.In addition,various kinds of period bifurcation phenomenon were displayed by ISIs.Results and Conclusions: The analysis results showed that there were apparent period doubling bifurcation and period adverse doubling bifurcation following the change of parameters in Na ion.Furthermore,after period doubling bifurcation and period adverse doubling bifurcation,the firing patterns returned to 1 period firing pattern.From the three-dimensional figures of gate variable of Na,with the increasing of gd,different bifurcation figures had the characteristics of similarity and time delay.

关 键 词：中间神经元 ISIS 倍周期分岔 三维分岔图 

分 类 号：R312[医药卫生—基础医学]