尼莫地平联合丁苯肽在治疗血管性认知功能障碍的观察  

Observation of the efficacy of the treatment of Nimodipine combined with DL-3n-Butylphthalide in patients with vascular cognitive impairment

作　　者：安晓雷[1] 李传玲[1] 

机构地区：[1]江苏省徐州市中心医院,徐州221009

出　　处：《神经病学与神经康复学杂志》2011年第1期10-12,共3页Journal of Neurology and Neurorehabilitation

基　　金：2009年徐州市科技计划资助项目(编号:XM09B066)

摘　　要：目的观察尼莫地平联合丁苯肽治疗血管性认知功能障碍的疗效。方法将90例血管性认知障碍的患者分为两组,对照组单用尼莫地平,治疗组予尼莫地平与丁苯肽联合应用。分别在治疗前及治疗后2个月进行蒙特利尔认知评估(MoCA)量表评测并比较结果。结果治疗组MoCA量表各子项目评分较对照组有提高,差异有统计学意义(P<0.05)。结论尼莫地平与丁苯肽联合应用较单用尼莫地平能进一步地改善血管性认知功能障碍患者认知功能的各个主要方面。Objective To observe the efficacy of Nimodipine combined with DL-3n-Butylphthalide in the treatment of patients with vascular cognitive impairment(VCI).Methods Ninety patients with VCI were divided into two groups,the control group was given nimodipine alone while the treatment group was given the Nimodipine combined with DL-3n-Butylphthalide.The scores of the Montreal Cognitive Assessment(MoCA) Scale were assessed before and two months after treatment.Results The sub-scale scores of MoCA in the treatment group were significantly improved than that in the control group(P<0.05).Conclusion The combination of Nimodipine combined with DL-3n-Butylphthalide can improve all-side of cognition than Nimodipine alone in patients with vascular cognitive impairment.

关 键 词：尼莫地平 丁苯肽 血管性认知功能障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]