短期联合抗栓治疗对急性进展性缺血性卒中发生率的影响  

Impact of short-term therapy of combining aspirin with clopidogrel on the incidence of acute progressive cerebral infarction

作　　者：周慧[1] 谷德祥[1] 

机构地区：[1]上海市杨浦区市东医院神经内科,上海200438

出　　处：《神经病学与神经康复学杂志》2011年第3期105-107,共3页Journal of Neurology and Neurorehabilitation

基　　金：杨浦区卫生局2009年度"名医师"工程课题项目(编号:2009152)

摘　　要：目的观察短期联合阿司匹林(ASA)和氯吡格雷(CPG)抗栓治疗对急性进展性缺血性卒中发生率的影响。方法入选新发急性非心源性缺血性卒中患者100例,随机分为联合抗栓组(ASA联合CPG)51例和标准治疗组(ASA联合安慰剂)49例,分别测评患者入院时及入院后1周的美国国立卫生研究院卒中量表(NIHSS)评分,比较两组间进展性卒中的发生率。结果两组在基线资料方面无差异,联合抗栓组发生进展2例,标准治疗组发生进展5例,两组间进展性卒中发生率差异显著(P<0.05)。结论短期联合抗栓治疗可以降低急性进展性缺血性卒中的发生率。Objective To investigate the impact of short-term therapy of combining aspirin(ASA) with clopidogrel(CPG) on the incidence of acute progressive cerebral infarction.Methods One hundred patients with acute non-cardiogenic ischemic stroke were randomly divided into the combined antithrombotic group(ASA combined CPG) and the standard treatment group(ASA combined placebo).The National Institutes of Health Stroke Scale(NIHSS) scores were evaluated in all the patients when admission and one week after admission to compare whether there were differences in the incidence of progressive cerebral infarction.Results There was no difference in the baseline data between the combined antithrombotic group(n=51) and the standard treatment group(n=49),there were two and five cases in the combined antithrombotic group and the standard treatment group respectively in the progressive ischemic stroke,there was difference in the incidence between the two groups(P<0.05).ConclusionShort-term therapy of combining ASA with CPG could reduce the incidence of acute progressive cerebral infarction.

关 键 词：进展性缺血性卒中 阿司匹林 联合抗栓治疗 

分 类 号：R743.3[医药卫生—神经病学与精神病学]