细胞色素P4502E1基因多态与贲门癌易感性关系探讨  

Study on the Relationship between Polymorphism of Cytochrome P4502E1 and Susceptibility of Gastric Cardia Cancer

作　　者：蔡琳[1] 郑宗立[1] 

机构地区：[1]福建医科大学流行病学教研室,福州350004

出　　处：《肿瘤防治研究》2004年第7期438-440,共3页Cancer Research on Prevention and Treatment

基　　金：全国优秀博士学位论文作者专项资金资助项目 (2 0 0 15 7) ;福建省自然科学基金资助项目 (C0 0 10 0 9)

摘　　要：目的　探讨细胞色素P4 5 0 2E1(CYP2E1)基因多态与贲门癌易感性的关系。方法　采用病例对照研究方法和聚合酶链反应 限制性片段长度多态性 (PCR RFLP)检测技术 ,对 15 9例贲门癌患者和 192例对照的CYP2E1基因多态性进行分析。结果　CYP2E13种基因型在贲门癌病例组和对照组的分布差异有显著性 (χ2 =16 .0 4 ,P <0 .0 1) ,比值OR为 2 .37(95 %CI :1.5 2～ 3.70 )。贲门癌病例组CYP2E1(c1/c1)基因型频率为 6 0 .4 % ,对照组为 4 0 .1%。吸烟且携带CYP2E1(c1/c1)基因型的个体与携带CYP2E1(c1/c2或c2 /c2 )基因型的不吸烟者相比 ,患贲门癌的OR为 4 .6 8(95 %CI:2 .19～ 10 .0 4 )。结论CYP2E1基因多态性与贲门癌易感性有关 。Objective To study the relationship between polymorphism of cytochrome P4502E1(CYP2E1) gene and susceptibility to gastric cardia cancer (GCC).Methods A case control study was used.The frequency of CYP2E1 genotype between patients with GCC and controls were detected by polymerase chain reaction restriction fragment polymorphism (PCR RFLP).Results The distribution of three genotypes of CYP2E1 in GCC and controls was significantly different ( χ 2= 16.04 , P < 0.01 ).The odds ratio were 2.37 (95% CI : 1.52 ～ 3.70 ).The frequency of CYP2E1 (c1/c1) genotype in GCC cases and controls was 60.4% and 40.1% respectively.Subjects who had CYP2E1(c1/c1) genotype and having smoking habit were at a significantly higher risk of developing GCC ( OR = 4.68 ,95% CI : 2.19 ～ 10.04 ) compared with those who had CYP2E1(c1/c2 or c2/c2) genotype and no smoking habit.Conclusion The ploymorphism of CYP2E1 gene was considered as one of the possible susceptible genes and the risk would increase significantly in smokers.

关 键 词：贲门癌 细胞色素P4502E1 基因多态 

分 类 号：R735.2[医药卫生—肿瘤]