Role of candesartan against cerebral ischemia and oxidative damage in normotensive rats  

出　　处：《Journal of Pharmaceutical Analysis》2008年第2期104-108,共5页药物分析学报（英文版）

摘　　要：Objective Angiotensin Ⅱ(Ang Ⅱ)contributes to modulating blood pressure by stimulation of Ang Ⅱ AT1 receptors.We devised a rat transient middle cerebral artery occlusion(MCAO)model to assess whether oxidative damage is decreased after pretreatment with Angiotensin Ⅱ AT1 receptor blocker(ARB).Methods After 2 weeks pretreatment with ARB 0.5 and 1mg/kg,the male Wister rats were subjected to 2h middle cerebral artery occlusion(MCAO).At 24h,the lumen diameter of middle cerebral artery,the plasma level of 8-hydrox...

分 类 号：R743[医药卫生—神经病学与精神病学]