牙周病与口腔癌相关性的Meta分析  

Meta-analysis of Association between Periodontal Disease and Oral Cancer

作　　者：曾宪涛[1] 高岭[2] 刘得玺[1] 郭毅[3,4] 罗志晓[1] 冷卫东[1] 

机构地区：[1]湖北医药学院附属太和医院口腔医学中心,湖北十堰442000 [2]西安交通大学医学院附属口腔医院颌面外科,陕西西安710004 [3]武汉大学公共卫生学院流行病学教研室,湖北武汉430071 [4]武汉大学病毒学国家重点实验室,湖北武汉430071

出　　处：《湖北医药学院学报》2012年第5期390-394,共5页Journal of Hubei University of Medicine

基　　金：湖北省教育厅科学技术研究计划2012年度重点项目(D20122405);湖北省教育科学"十二五"规划2012年度重点课题(2012A049);湖北医药学院2011年度优秀中青年科技创新团队项目(2011CZX01)

摘　　要：目的:采用Meta分析的方法探讨牙周病与口腔癌的相关性。方法:检索PubMed和CBM数据库中自建库至2012年6月30日之间公开发表的文献,对符合纳入标准的研究进行质量评价及数据提取后,采用Comprehensive Meta Analysis v2.2软件进行Meta分析。结果:最终纳入5个病例-对照研究,质量均较高。校正了其他危险因素的Meta分析结果显示,暴露于牙周病的人群罹患口腔癌的风险增加了2.66倍(OR=2.66,95%CI=1.12～6.35);未校正的则增加了5.05倍(OR=5.05,95%CI=2.39～10.66)。敏感性分析显示结果稳健性好,未行发表偏倚分析。结论:当前证据表明牙周病很可能是口腔癌的一个独立的、有意义的危险因素。Objective To explore the association between periodontal disease and oral cancer by using meta-analysis approach.Methods The PubMed and CBM databases were searched for relevant studies up to June 30,2012.After quality assessment and data extraction for included studies,a meta-analysis was performed by using the Comprehensive Meta Analysis v2.2 software.Results Finally 5 case-control studies were recruited,all the quality were morderate to high.The result of meta-analysis of adjusted data showed that exposed periodontal diseases can obviously increase of risk for oral cancer 2.66 times(OR=2.66,95%CI=1.12~6.35),and 5.05 times for unadjusted data(OR=5.05,95%CI=2.39~10.66).Sensitivity analysis showed the results were robust,the publication bias was not conducted.Conclusion Based on current evidence,periodontal diseases is likely an independently and significantly risk factor for oral cancer.

关 键 词：牙周病 口腔癌 危险因素 META分析 

分 类 号：R739.8[医药卫生—肿瘤]