HPV-DNA分型检测在ASCUS患者分流管理中的价值  

Value of Human Papillomavirus Testing in Triage of Atypical Squamous Cell of Undetermined Significance

作　　者：王华[1] 郭广林[1] 任红英[1] 庞雁[1] 王玉婷[1] 

机构地区：[1]湖北医药学院附属襄阳医院妇产科,湖北襄阳441100

出　　处：《湖北医药学院学报》2012年第4期310-312,共3页Journal of Hubei University of Medicine

摘　　要：目的:评价人乳头瘤病毒(HPV)DNA分型检测在未明确诊断意义的宫颈非典型鳞状上皮细胞(atypicalsquamous cells of undetermined significance,ASCUS)患者中的应用价值。方法:对薄层液基细胞学检查结果为AS-CUS的患者进行阴道镜检查及组织病理学检查,并同时行HPV-DNA分型检测。结果:⑴165例ASCUS患者中,组织学诊断为慢性宫颈炎、湿疣、CINI、CINII中HPV-DNA的检出率分别为9.0%、66.7%、76.7%、90.0%;⑵组织学诊断为CINIII和侵袭性子宫颈癌(invasive cervical cancer,ICC)的患者HPV-DNA检出率均为100%,与CINI和CI-NII相比,差异有统计学意义(P<0.05);⑶HPV检测CIN和ICC的灵敏度为94.7%,特异度70.1%,阳性预测值27.4%,阴性预测值99.0%。结论:HPV-DNA分型检测可有效检出宫颈细胞学ASCUS中CIN及宫颈癌患者,可对患者进行有效分流管理。Objective To evaluate the clinical value of HPV-DNA testing in the distribution and management of atypical squamous cell of undetermined significance(ASCUS).Methods The patients diagnosed as ASCUS by liquid-based cytologic test received colposcopy for tissue studies and were examined with HPV-DNA testing simultaneously.Results ⑴The detective rates of HPV was 9.0% and 66.7% in chronic cervicitis and condylomatous disease,76.7% and 90.0% in CINI and CINII,respectively.There were statistically difference between two stage of cevercal lesions(P<0.05).⑵The positive rate of HPV testing was both 100% in cervical cancer and CINIII,there was statistical difference compare with CINI and CINII.⑶The sensitivity,specificity,positive predictive value and negative predictive value of HPV testing in diagnosed CIN and ICC were 94.7%,70.1%,27.4% and 99.0%,respectively.Conclusion HPV-DNA can effectively screen CIN and cervical cancer cases from ASCUS,which is an effective method for the distribution and management of ASCUS patients.

关 键 词：宫颈病变 未明确诊断意义的宫颈非典型鳞状上皮细胞 人乳头瘤病毒 宫颈上皮内瘤变 

分 类 号：R737.33[医药卫生—肿瘤]