线粒体与神经退行性疾病  

Mitochondria and Neurodegenerative Diseases

作　　者：周晓雯[1] 苏朝芬[1] 罗焕敏[1,2] 

机构地区：[1]暨南大学医学院药理学系 [2]暨南大学-香港大学脑功能与健康联合实验室

出　　处：《神经药理学报》2011年第3期41-46,共6页Acta Neuropharmacologica

基　　金：国家自然科学基金项目(No.81173037);广东省科技计划项目(No.2010B030700018)

摘　　要：神经退行性疾病是由神经元和/或其髓鞘的丧失所致,目前该类疾病的病因仍未完全阐明。研究发现,线粒体功能障碍、能量代谢异常,已成为公认的早期病理现象。本文主要以阿尔茨海默病(Alzheimer’s disease,AD)和帕金森综合症(Parkinson’s disease,PD)为例,探讨线粒体功能异常在神经退行性疾病发病中的作用,以期为该类疾病诊治和新药研发提供新思路。The neurodegenerative diseases are usually caused by the loss of the neurons and/ or their myelin sheath,but the pathogenesis of these diseases is still indeterminate.Studies so far have proved that mitochondrial dysfunction and energy metabolism disorders are early pathological phenomena.This review concentrates on two of the most prevalent neurodegenerative diseases:Alzheimer’s disease(AD)and Parkinson’s disease(PD)and would be aimed to discuss the role of mitochondrial in pathogenesis of neurodegenerative diseases,providing new direction for further research.

关 键 词：线粒体 阿尔茨海默病 帕金森综合症 

分 类 号：R741[医药卫生—神经病学与精神病学]