短暂性脑缺血发作患者血小板微颗粒水平的研究  

Study of Platelet Microparticle Levels in Patients with Transient Ischemic Attacks

作　　者：陈蓓蕾[1] 李晓波[1] 顾健[1] 马莉[1] 

机构地区：[1]江苏省苏北人民医院神经科,扬州225009

出　　处：《血栓与止血学》2011年第6期258-261,共4页Chinese Journal of Thrombosis and Hemostasis

基　　金：江苏省科技支撑计划课题(BE2009653);江苏省卫生厅预防医学科研课题资助(YZ201021)

摘　　要：目的研究短暂性脑缺血发作(transient ischemic attacks,TIA)患者的血小板微颗粒(platelet microparti-cle,PMP)水平及其临床意义,并了解钙离子拮抗剂(calcium channel blockers,CCB)对TIA患者PMP的水平的影响。方法检测并比较80例TIA患者及80例健康人PMP及CD62P、GPⅡb/Ⅲa水平。比较29例进展为脑梗死的TIA患者及51例未进展为脑梗死的TIA患者的PMP及CD 62P、GPⅡb/Ⅲa水平。检测26例给予CCB治疗的TIA患者的PMP水平,并与25例未使用CCB治疗的患者的PMP水平进行比较。结果与健康对照组相比TIA患者的PMP及CD62P、GPⅡb/Ⅲa水平较高,且PMP水平较高者更易进展为脑梗死。TIA患者使用CCB治疗14 d后PMP水平较对照组明显降低。结论 TIA患者存在血小板活化,检测血液PMP水平将有助于我们判断TIA的预后。CCB能降低TIA患者PMP水平。Objective To study serum levels and their clinical significance of platelet microparticle(PMP) in transient ischemic attacks(TIA)patients.To know the impact of calcium channel blockers(CCB) on the PMP levels of TIA patients. Methods The serum levels of PMP,CD 62P and GPⅡb/Ⅲa were detected and compared between TIA group consisting of 80 patients and control group consisting of 80 health persons.The PMP,CD 62P and GPⅡbⅢa levels of 29 TIA patients who have evolved to cerebral infarction were detected and compared to the PMP,CD 62P and GPⅡb/Ⅲa levels of 51 TIA patients who haven't got infarction.The PMP levels of 26 TIA patients who were given CCB were detected and compared to the PMP levels of 25 patients who haven't take CCB. Results Compared with the control,the serum levels of PMP,CD 62P and GPⅡb/Ⅲa were higher in TIAs,and the higher the levels were,the more likely to evolve to infarction.The PMP levels of patients who had been given 14 days treatment of CCB were obviously lower than the level in those who had't taken CCB. Conclusion Platelet is activated in TIAs.Testing the serum levels of PMP helps to predict the outcomes of TIAs.CCB helps to reduce the PMP levels of TIA patients.

关 键 词：短暂性脑缺血发作 血小板活化 血小板微颗粒 钙离子拮抗剂 

分 类 号：R743[医药卫生—神经病学与精神病学]