瑶宝血脂清胶囊降低血清中胆固醇作用的研究  

Yaobao Xuezhiqing Capsules on Reducing Cholesterol in Serum

作　　者：徐瑞鑫[1] 卞宏生[1] 李廷利[1] 

机构地区：[1]黑龙江中医药大学药学院,黑龙江哈尔滨150040

出　　处：《中医药学报》2011年第4期41-43,共3页Acta Chinese Medicine and Pharmacology

摘　　要：目的:探究瑶宝血脂清胶囊降低血清中胆固醇的作用与作用机制。方法:采用大鼠灌胃高脂乳剂的方法,复制实验性高脂血症模型,在灌胃高脂乳剂的同时,灌胃瑶宝血脂清胶囊的水溶液,连续7天,监测给药第0、3、5、7天血清中总胆固醇(TC)含量的动态变化,并检测7天后血清中高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)以及粪便中(TC)的含量。结果:灌胃给药瑶宝血脂清胶囊7天后,血清中的总胆固醇含量最低,瑶宝血脂清胶囊能明显降低血清中的LDL-C,而对HDL-C作用不明显,给药后能明显增加体内的TC随粪便的排出。结论:瑶宝血脂清胶囊降血脂作用与降低血清中低密度脂蛋白胆固醇和促进体内的TC随粪便排泄有关。Objective:Experimental studies on hypolipidemic mechanism of Yaobao Xuezhiqing capsules.Methods:Using the method of gavage rats with high-fat emulsion to make rat models of hyperlipidemia.At the same time,gavage rats with water solution lasted 7 days,monitoring TC contents in blood-serum on 0,3rd,5th and 7th day,and detecting TC in excrement,HDL-C and LDL-C in blood-serum after 7days.Results:The content of TC in blood-serum at the lowest level after gavage rats with water solution of Yaobao Xuezhiqing capsules for 7 days.Yaobao Xuezhiqing capsules have a significant activity in owering serum LDL-C but has no effect on HDL-C.Administration can obviously increase total cholesterol egest with excrement.Conclusion:The hypolipidemic mechanism of Yaobao Xuezhiqing capsules is related lowering LDL-C in blood-serum and increasing TC egest with excrement.

关 键 词：瑶宝血脂清胶囊 降血脂 粪便 作用机制 

分 类 号：R28[医药卫生—中药学]