血管紧张素Ⅱ1型受体A1166C多态性在云南彝族人群中的分布  

Distribution of Angiotensin Ⅱ Type 1 Receptor Gene A1166C Polymorphism in Yi Nationality Population in Yunnan Province

作　　者：杨榆玲[1] 龙莉[1] 瞿秋[2] 吴玲[2] 何永蜀[1] 张彦[1] 

机构地区：[1]昆明医科大学细胞生物学及遗传学教研室,云南昆明650031 [2]昆明医科大学第一附属医院干疗科,云南昆明650032

出　　处：《昆明医科大学学报》2012年第5期43-46,共4页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81160164);云南省自然科学基金资助项目(2008CD117);昆明医科大学大学生创新性实验计划项目(CX201116)

摘　　要：目的了解云南省晋宁县彝族人群AT1R基因A1166C多态性分布的情况,为研究AT1R基因相关性疾病的发病机制奠定基础.方法采用PCR-RFLP技术对居住在云南省晋宁县180例彝族健康个体的AT1R基因A1166C多态性进行分析,获得其基因型频率和等位基因频率分布情况,并与其他人群该位点多态性进行比较.结果云南省晋宁县彝族AT1R基因的AA、AC、CC基因型频率分别为95.6%、4.4%和0%,A、C等位基因频率分别为97.8%和2.2%.此位点多态性分布与不同人群比较,除凉山彝族外,差异均有统计学意义(P<0.05).结论 AT1R基因A1166C多态性分布存在民族、种族差异.Objective To investigate the angiotensin II type 1 receptor(AT1R)gene A1166C polymorphism in a Yi nationality population in Yunnan province,and to provide evidence for the research of AT1R related diseases.Methods We recruited 180 healthy subjects of Yi nationality in rural area of Jinning,Yunnan province.The AT1R A1166C polymorphism was determined by polymerase chain reaction-restriction fragment(PCR-RFLP)technique.The genotype frequencies and allele frequencies were obtained and compared with those collected from other population.Results In healthy Yi people of Yunnan province,frequencies for the AA,AC and CC genotypes were 95.6%,4.4% and 0%.Derived allele frequencies for the A and C allele were 97.8% and 2.2%.The distribution of AT1R genotypes and the allele frequencies in Yunnan Yi people were significantly different from other nationality(P<0.05).Conclusion The frequency of the genotype or the allele of AT1R A1166C polymorphism is different significantly in different ethnic populations.

关 键 词：AT1R基因 遗传多态性 彝族 分布 

分 类 号：R181.3[医药卫生—流行病学]