中老年教师高血压伴短暂性脑缺血患者颅内动脉狭窄及其相关危险因素  

Intracranial arterial stenosis of elderly teachers with hypertension and transient ischemic attack and its associated risk factors

作　　者：李清锋[1] 梁烨[2] 李天资[2] 潘兴寿[2] 卢冠铭[3] 黄照河[2] 韦世革[2] 陆荣臻[3] 刘燕[2] 赖腾芳[2] 

机构地区：[1]右江民族医学院临床学院放射科,广西百色530000 [2]右江民族医学院临床学院心内科,广西百色530000 [3]右江民族医学院临床学院手麻科,广西百色530000

出　　处：《中华临床医师杂志（电子版）》2012年第19期5903-5911,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金(81060028);广西自然科学基金(桂科自0542120)

摘　　要：目的探讨中老年教师原发性高血压(PH)伴短暂性脑缺血(TIA)患者颅内动脉狭窄的患病情况及其与慢性血管疾病危险因素的关系。方法对110例PH伴TIA中老年教师患者进行颅内动脉CT血管造影(CTA)、身高、体重、总胆固醇(TC)、甘油三酯(TG)、空腹血糖(FBS)和血尿酸(SUA)检测,将结果分为颅内动脉狭窄与非狭窄两组并进行探索性分析。结果共有67例103处颅内血管有轻度以上狭窄,其中有1处狭窄44例,2处15例,3处4例,4处3例,5处1例;狭窄程度:轻度32例,中度23例,重度8例,闭塞4例;狭窄血管:颈内动脉60例(占54.5%),椎动脉15例(占7.3%),大脑中动脉12例(占10.9%),大脑后动脉9例(占8.2%),前交通动脉9例(占8.2%),大脑前动脉3例(占2.7%)和后交通动脉3例(占2.7%),不同部位动脉狭窄发生率差异有统计学意义(χ2=151.959,P=0.000),不同部位不同性别动脉狭窄发生率差异无统计学意义(P>0.05),动脉狭窄组其体质指数(BMI)、TC、TG、FBS和SUA的平均值较非动脉狭窄组高(P均<0.01)。回归分析结果:高血压和SUA、TC、BMI、FBS与颅内血管的狭窄有协同作用(P<0.01)。结论中老年教师PH伴TIA颅内动脉狭窄患病率为55.8%,颅内动脉狭窄患者,其BMI、TC、TG、FBS和SUA的平均值较非动脉狭窄组高,SUA、TC和FBS是PH伴TIA颅内动脉狭窄的重要危险因素,高血压和SUA、TC、BMI、FBS与颅内动脉狭窄有协同作用。Objective To investigate the prevalence of intracranial arterial stenosis of teachers with primary hypertension(PH)and transient ischemic attack(TIA)and its associated chronic vascular disease risk factors.Methods CT angiography(CTA),height,weight,total cholesterol(TC),triglycerides(TG),fasting blood sugar(FBS)and serum uric acid(SUA)detection was performed on 110 teachers with PH and TIA.The data was divided into intracranial arterial stenosis group and no-intracranial arterial stenosis groups according to the detection results and then performed exploratory analysis.Results A total of 103 intracranial vascular in 67 cases was mild above narrow,that was 44 cases with 1 narrow,15 cases with 2 narrow,3 cases with 4 narrow,4 cases with 3 narrow,1 cases with 5 narrow;the degree of stenosis:32 cases of mild narrow,23 cases of moderate,and severe in 8 cases,4 cases of occlusion;stenosis:60 cases of internal carotid artery(54.5%),vertebral artery in 15 cases(7.3%),middle cerebral artery in 12 cases(10.9%),posterior cerebral artery in 9 cases(8.2%),anterior communicating artery in 9 cases(8.2%),anterior cerebral artery in 3 cases(2.7%)and posterior communicating artery in 3 cases(2.7%),different parts of the arterial stenosis incidence statistically significantly difference(χ2=151.959,P=0.000),artery stenosis incidence in different parts and different gender was not statistically significantly difference(P>0.05),average of BMI,TC,TG,FBS and SUA of artery stenosis group was higher than non-artery stenosis group(all P<0.01).Result of regression analysis:high blood pressure and SUA,TC,BMI,FBS and intracranial vascular stenosis had a synergistic effect(P<0.01).Conclusions Intracranial arterial stenosis prevalence rate of elderly teachers with PH and TIA is 55.8%,average of BMI,TC,TG,FBS and SUA of artery stenosis group is higher than non-artery stenosis group.SUA,TC,FBS are important risk factors for PH with TIA intracranial arterial stenosis,high blood pressure and SUA,TC,BMI,FBS have synergistic effect with intracranial

关 键 词：高血压 脑缺血发作 短暂性 颅内动脉疾病 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]