姜黄素衍生物的合成及其抗肿瘤活性  

Synthesis and anti-tumor activity of curcumin derivatives

作　　者：魏冬[1] 姜波[1] 薛璇[1] 汪佳凤[1] 周双生[1] 

机构地区：[1]现代中药安徽省工程技术中心,安徽中医学院药学院,安徽合肥230031

出　　处：《合肥师范学院学报》2012年第6期77-80,共4页Journal of Hefei Normal University

基　　金：安徽省省级高校自然科学研究重点项目(KJ2010A222);安徽省自然科学基金项目(1208085MH173);安徽中医学院自然科学研究重点项目(2011zr005A)

摘　　要：以姜黄素、溴乙烷、苄基氯等为原料,制备了二种新型姜黄素衍生物B和C,经核磁、红外和质谱确定了目标化学物结构;运用计算机化学药物设计软件MOE评价了化合物与乙二醛酶的1Q1N蛋白分子结合能力,并使用MTT法对其抗肿瘤活性进行测试。Two kinds of curcumin derivaties were prepared using curcumin,ethyl bromide,benzy chloride and so on as starting material,the target compouds were confirmed by IR,1HNMR and Mass Spectrometry.The binding abilities of the compouds with the protein 1Q1N of Glyoxalase were determined using by using a kind of computer chemical drug designing software MOE(Molecular Operating Environment),at the same time,the anti-tumor activity of the target compounds were measured by the MTT method.

关 键 词：姜黄素衍生物 合成 分子对接 抗肿瘤活性 

分 类 号：R285[医药卫生—中药学]