绿脓杆菌外毒素A的最新研究进展  

Recent Advances on Pseudomonas exotoxin A

作　　者：夏海华[1] 于冲[1] 曲晓军[1] 孙建华[1] 王金英[1] 

机构地区：[1]黑龙江省科学院微生物研究所,黑龙江哈尔滨150010

出　　处：《生物技术》2012年第2期81-85,共5页Biotechnology

基　　金：黑龙江省科学院研究基金项目("11种血清型绿脓杆菌PEA基因序列与其活性的关系研究")资助

摘　　要：在免疫缺失、囊肿性纤维化、烧伤烫伤等患者的临床继发感染中,绿脓杆菌是引起感染的主要病原菌之一,其合成的细胞外毒性物质—绿脓杆菌外毒素A(PEA)被认为是引起感染的最关键内在机制。该文对中外学者们在PEA的结构、功能、提取和纯化方法、重组毒素、基因工程疫苗以及应用等方面的研究进行归纳总结,并对研究和应用中存在的问题加以分析,对预防和治疗绿脓菌感染、抗肿瘤、抗移植排斥和治疗自身免疫性疾病等具有重要而深远的意义。Pseudomonas aeruginosa is the main pathogen that caused infected in patients who suffering from cystic fibrosis,burns,immune deficiency,Synthesis of extracellular toxic substances-Pseudomonas exotoxin A(PEA) is considered to be the most critical intrinsic mechanism caused by infection.Chinese and foreign scholars have researched deeply on the structure,function,method of extraction and purification,recombinant toxin,genetically engineered vaccine,and aplication of PEA,the problems of research and application have to be analyzed.It has important and far-reaching significance for preventing and treating of Pseudomonas aeruginosa infection,resisting tumor,resisting transplant rejection and treating of autoimmune diseases.

关 键 词：绿脓杆菌外毒素A(PEA) 结构 功能 提取 纯化 重组毒素 基因工程疫苗 应用 

分 类 号：R378[医药卫生—病原生物学]