γ-分泌酶的重要组成部分PS  

PS,Important Subunits of γ-Secretase

作　　者：张锦巍[1] 张军[2] 李聪[1] 井丽娟[1] 孙亚平[1] 高健[1] 董贵成[1] 

机构地区：[1]内蒙古科技大学包头师范学院,中国内蒙古包头市014030 [2]包头市第四医院,中国内蒙古包头市014030

出　　处：《生物技术世界》2012年第5期16-18,共3页Biotech World

基　　金：国家自然科学基金项目(30960334);内蒙古自然科学基金项目(2009BS1105);"2009年教育部新世纪优秀人才支持计划"(NCET-09-0857)

摘　　要：阿尔茨海默病(Alzheimer’s Disease,AD)与遗传因素密切相关。研究发现,大多数早发性家族性AD(FAD)和部分散发性AD(SAD)患者存在γ-分泌酶特别是早老素蛋白(presenilin,PS)基因突变。PS基因变异可引起β-淀粉样蛋白前体蛋白的加工和运输异常,产生过多的β-淀粉样蛋白(Aβ)而形成老年斑。对于SAD,PS表达的改变引起细胞骨架蛋白(如tau蛋白)之间的相互作用异常,而与神经纤维缠结(NFT)的形成有关。另外,PS使神经细胞对凋亡刺激的敏感性增强,以及PS基因突变产生过多的Aβ能引起脑内Bax表达增强,促进神经细胞的凋亡过程,引起AD脑内广泛的神经元减少或丢失。因此,PS在AD的发病中起到重要作用。Alzheimer's disease (Alzheimer's Disease, AD) and genetic factors are closely linked. The study found that the majority of early-onset familial AD (FAD) and some sporadic AD (SAD) patients had Alzheimer-like protein (presenilin, PS) gene mutations. PS gene mutation can cause β-amyloid precursor protein processing and transport anomalies, resulting in an excess of β-amyloid (Aβ) and the formation of senile plaques.For SAD,PS to changes in the expression of cytoske letalproteins(eg tauprotein)the interaction between the abnormal, but not with neurofibrillary tangles (NFT) of the formation. In addition, PS to stimulate the nerve cells to apoptosis sensitivity increased, as well as the PS mutations result in excessive Aβ can cause brain increased expression of Bax, promote apoptosis of nerve cells, causing a wide range of neurons in AD brain to reduce or lost.So. PS in the pathogenesis of AD play an important role.

关 键 词：阿尔茨海默 Γ-分泌酶 PS 

分 类 号：R749.16[医药卫生—神经病学与精神病学]