胃癌组织中抗凋亡蛋白livin的表达及临床意义  

Expression and significance of livin in human gastric carcinoma

作　　者：雷俊华[1,2] 曾江正[1,2] 周东升[1,2] 洪涛[1,2] 何志惠[1,2] 

机构地区：[1]海南医学院附属医院血液肿瘤内科 [2]海南医学院肿瘤研究所,海南海口570102

出　　处：《现代预防医学》2012年第22期5906-5908,5908,共3页Modern Preventive Medicine

基　　金：海南省卫生厅项目(琼卫2009-61)

摘　　要：目的探讨胃癌组织中抗凋亡蛋白livin的表达及生物学意义。方法采用原位杂交技术和免疫组织化学方法检测49例胃癌组织和20例正常胃组织中的livin基因及蛋白表达。结果 49例胃癌组织中,livin蛋白表达阳性率为49.0%(24/49),livinmRNA表达阳性率为46.9%(23/49),正常胃组织中呈低表达,阳性率为20%(4/20)。Livin表达与肿瘤大小及淋巴结转移有关(P﹤0.05)。结论 Livin基因及蛋白在胃癌中表达上调,提示在胃癌的发生、发展中起重要作用,有望成为一种有效敏感的肿瘤标记物,可作为判断胃癌预后的新分子标记物和胃癌诱导凋亡治疗的新靶点。OBJECTIVE To explore the expression of apoptosis inhibition protein Livin in gastric cancer.METHODS The expression of Livin was studied in 49 gastric cancer samples and 20 adjacent normal tissues by in situ hybridizationtechniques and immuohistochemisitry.RESULTS The expression of Livin protein in gastric cancer was significantly higher than that of adjacent normal tissues(49.0% vs 20.0%,P﹤0.05);The expression of livin-mRNA was 46.9%(23/49)Livin protein expression was positive correlation with the sizes of tumor and lymphatic metastasis(P﹤0.05).CONCLUSION The overexpression of Livin protein in gastric cancer indicated it may play an important role in carcinogenesis and progression of gastric cancer.Therefore,livin may be an index for identifying gastric carcinoma.As a molecularmarker of gastric carcinoma,livin maybe served as a new target for apoptosis inducing therapy of gastric carcinoma.

关 键 词：胃癌 抗凋亡蛋白livin 表达 

分 类 号：R735.2[医药卫生—肿瘤]