低浓度多柔比星硬膜外注药用于癌症椎体转移患者的临床研究  

The clinical research of low concentrations of doxorubicin Star epidural injection in the treatment of cancer patients with vertebral metastasis

作　　者：陈杰[1] 

机构地区：[1]河北工程大学附属医院麻醉科,河北邯郸056029

出　　处：《现代预防医学》2012年第22期5992-5994,5999,共3页Modern Preventive Medicine

基　　金：邯郸市科技局2008年立项基金(0823108060-3)

摘　　要：目的观察低浓度多柔比星硬膜外入药治疗癌症椎体转移患者疼痛程度的临床效果。方法选择某院自2008年1月～2011年12月乳腺科治疗的28例乳腺癌合并椎体转移的患者,按照患者的自愿原则,将患者随机分为观察组与对照组,每组14例。观察组术后采用低浓度多柔比星(10～20mg)+甲磺酸罗哌卡因+芬太尼行硬膜外神经阻滞治疗,对照组采用传统的治疗方法吗啡+多柔比星静脉治疗。对两组患者在镇痛效果、用药量、生存质量以及心脏毒性等方面进行比较分析,观察两组的临床效果。结果采用数字分级法(NRS)对两组患者的疼痛程度进行评分,观察组治疗前后NRS评分分别为(6.88±1.66)、(2.41±1.78)分,对照组治疗前后NRS评分分别为(7.01±2.02)、(4.22±1.96)分,两组比较差异有统计学意义(P﹤0.05);观察组患者的生活质量明显提高(t=2.589,P﹤0.05);两组无临床症状的并发症的发生。结论低浓度的多柔比星硬膜外给药,治疗乳腺癌患者癌症椎体转移,其抗癌活性及疗效与传统比较,患者的生存质量明显改善,疼痛程度大大减轻,是一种经济实用、安全有效的方法。OBJECTIVE To observe the clinical effect of low concentrations of doxorubicin Star epidural injection in the treatment of cancer patients with vertebral metastasis.METHODS 28 cases of patients with breast cancer with vertebral metastasis in the surgical departments of our hospital from January 2008 to December 2011 were chosen as the research objects.In accordance with the principle of the patient's voluntary,the patients were randomly divided into observation group and control group(n = 14 cases).The observation group was treated with low concentrations of doxorubicin(10 to 20mg)+ A ropivacaine + fentanyl epidural anesthesia treatment,the control group was taken with the traditional treatment of morphine + and more supple than the Star vein treatment.The nalgesic effects,dosage,quality of life and cardiac toxicity of the patients were taken for a comparative analysis.The clinical effect of two groups was observed.RESULTS The degree of pain of the two groups was taken with digital grading results(NRS)score.The NRS score before and after the observation group respectively were(6.88 ± 1.66)and(2.41 ±1.78).The NRS score in the control group before and after treatment were(7.01 ± 2.02)(4.22 ± 1.96).The differences of the two groups were significantly(P﹤0.05).The quality of life in patients improved significantly(t = 2.589,P﹤0.05).There was without clinical symptoms with complications.CONCLUSION The low concentrations of doxorubicin Star epidural injection in the treatment of cancer patients with vertebral metastasis is with vertebral metastasis,its anticancer activity and efficacy was compared with traditional comparison.The patient's quality of life improved significantly,the degree of pain greatly was reduced.It is an economical and practical safe and effective method.

关 键 词：癌症椎体转移 硬膜外 低浓度 多柔比星 

分 类 号：R730.5[医药卫生—肿瘤]