NOS2A基因启动子区基因多态性与缺血性脑卒中关系的研究  

A study of the association of the polymorphisms of NOS2A gene with ischemic stroke

作　　者：阚春燕[1] 高鹏[2] 袁冬[1] 杜丹华[1] 吴江[1] 

机构地区：[1]吉林大学白求恩第一医院神经内科,吉林长春130021 [2]吉林大学白求恩第一医院内分泌科,吉林长春130021

出　　处：《中风与神经疾病杂志》2012年第2期113-115,共3页Journal of Apoplexy and Nervous Diseases

基　　金：国家自然科学基金(3080037);吉林省科技厅项目(20080161);吉林省卫生厅项目(2008p008)

摘　　要：目的以SNPs为遗传标记,探讨NOS2A基因多态性与缺血性脑卒中的关系。方法以NOS2A启动子区-969G/C,-1173C/T的两个位点为遗传标记,通过对NOS2A基因启动子区进行全长测序以分析这两个位点的基因型。结果 -969G/C,-1173C/T不是中国北方汉族人的SNP位点,NOS2A-969C位点的等位基因均为T,NOS2A-1173C位点的等位基因均为G。我们在NOS2A基因启动子区检测到了rs2779248位点,关联分析表明rs2779248位点与缺血性脑卒中无相关性。结论 NOS2A基因启动子区与缺血性脑卒中的发病无明显相关。Objective To investigate the association of the polymorphisms of NOS2A gene with ischemic stroke.Methods We selected two SNPs,-969G/C and-1173C/T,as DNA markers.Whole length sequencing analysis of the promoter region was applied to genotype these two SNPs.Results Both-969G/C and-1173C/T were not SNPs of Chinese Han descent,while rs2779248 was found in the promoter of NOS2A gene.But the cocaphase analysis showed no signficant association of rs2779248 with ischemic stroke.Conclusion The data suggests that genetic variants within the promoter of NOS2A are not the risk factors for ischemic stroke in Chinese Han ancestry.

关 键 词：诱导型一氧化氮合酶 基因 缺血性卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]