2A型多发性内分泌腺瘤病超声表现  

Ultrasonographic features of multiple endocrine neoplasia 2A

作　　者：张金双[1] 李雪[2] 吴筱辉[1] 王珊珊 黄友梅[1] 李萌[1] 周君[1] 苏冬明 

机构地区：[1]解放军第一一七医院超声科,杭州310004 [2]空军杭州疗养院特诊科 [3]浙江省杭州市西溪医院B超室

出　　处：《中华医学超声杂志（电子版）》2013年第3期231-233,共3页Chinese Journal of Medical Ultrasound(Electronic Edition)

摘　　要：目的总结2A型多发性内分泌腺瘤病(MEN)的超声声像图特征。方法回顾性分析解放军第一一七医院经基因检测均为Ret第11号外显子C634Y突变的12个家族中的57例2A型MEN患者甲状腺及肾上腺超声表现。所有患者均经病理证实。结果 57例2A型MEN患者单侧或双侧甲状腺均可见单发或多发低回声或混合性回声结节,18例合并肾上腺单侧或双侧单发或多发低回声或混合性占位。经手术病理或超声引导穿刺活检证实单侧或双侧甲状腺髓样癌51例(89.5%),甲状腺髓样癌并甲状腺乳头状癌4例(7.0%),甲状腺C细胞增生2例(3.5%),淋巴结转移4例(7.1%),单侧或双侧肾上腺嗜铬细胞瘤18例(31.6%)。结论 2A型多发性内分泌腺瘤病超声表现具有特异性,超声检查可早期提示此病。ObjectiveTo explore the sonographic features of multiple endocrine neoplasia 2A(MEN2A).MethodsThe sonographic findings of MEN2A in 57 cases the 117th Hospital of People′s Liberation Army with Ret-C634Y mutation were summarized retrospectively.These patients involved 12 families.All patients were proved by pathology.ResultsThyroid nodules were found in all 57 cases,which presented with various quantity(single or multiple),echogenecity(hypoechoic or mixed)and location(unilateral or bilateral).Eighteen patients had single or multiple adrenal nodules with unilateral or bilateral distribution.On pathology,the diagnoses were:unilateral or bilateral medullary thyroid carcinoma in 51 cases(89.5%),medullary carcinoma of thyroid and papillary carcinoma of thyroid in 4 cases(7.0%),thyroid C cell hyperplasia in 2 cases(3.5%),lymph node metastasis in 4 cases(7.1%),unilateral or bilateral pheochromocytomas in 18 cases(31.6%).ConclusionsMEN2A has some specific features on sonography.Ultrasound may be useful in the early diagnosis of this disease.

关 键 词：超声检查 多发性内分泌腺瘤病2A型 甲状腺 肾上腺 

分 类 号：R445.1[医药卫生—影像医学与核医学] R736[医药卫生—诊断学]