胃复春对胃癌癌前病变的治疗及对p21^(ras)、p53表达的调节作用研究  

A Study of Weifuchun in the Treatment of Gastric Precancerous Lesions and Regulating Effect on p21^(ras) and p 53 Protein Expression

作　　者：张运贵[1] 张瑞玲[1] 黄咏梅[1] 段学萍[1] 薛强[1] 孙兆田[1] 

机构地区：[1]济南市第四人民医院,济南250031

出　　处：《临床消化病杂志》2004年第4期161-162,183,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的:研究胃复春片对胃黏膜中、重度异型增生的治疗作用及对p 21ras、p 53蛋白表达的调节作用.探讨其逆转胃癌癌前病变的治疗价值及机制。方法:内镜下病理活检证实为中、重度异型增生患者共58例,随机分为胃复春治疗组32例,维酶素对照组26例。治疗前后比较临床疗效,镜下改变,病理改变及胃黏膜固定部位活检标本p 21ras、p 53蛋白s-P法免疫组化染色变化情况。结果:胃复春组临床症状的总有效率81.25％,内镜下改变总有效率71.88％,病理学改变总有效率65.63％,均优于维酶素对照组(分为53.85％、46.15％、34.61％)。p 21ras、P53蛋白在中、重度异型增生组织中有过度表达,胃复春能使其表达明显减弱。结论:胃复春对胃黏膜中、重度异型增生有良好的治疗作用,能促进病变胃黏膜的逆转,并对p21ras、p 53蛋白的表达有一定的调节作用,降低癌变危险性,可用于胃癌癌前病变的治疗。Objective:To determine the effect of weifuchun in the treatment of gastric mucosa with dysplasia and regulating effect on p 21rasand p53 protein expression.Methods:48 patients with endoscopically and pathologically confirmed moderate and severe dysplasia are classified randomly into 2 groups . Among them 32 patients were treated with weifuchun and 26 patients with weimeisu as control. Expression of p 21ras and p 53 proteints were detected by S-P immuno histochemical method before and after treatment . Results: The effect of clinical symptoms , pathological and endoscopical changes were better in treatment group than that in control group . The overexpression of p 21ras and p53 proteins are found in both groups before treatment and weifuchun reduced both of them. Conclusion: Weifuchun had p 21ras and p53 endoscopical lesions of gastric mucosal dysplasia and regulating effect on the expression of p21ras and p53 proteins to some extent.It could reduce the risk of carcinogenesis of gastric precancerous lesions so that it was and effective and safe medicine.

关 键 词：胃黏膜异型曾生 胃复春 P21^RAS P 53 

分 类 号：R735.2[医药卫生—肿瘤]