香叶制剂对中重度慢性牙周炎血清MMP-8变化影响的研究  

Research of the Influence of Clove Preparation on Moderate to Severe Chronic Periodontitis Serum MMP-8

作　　者：刘砚芝 杨续艳[2] 鲍莉 

机构地区：[1]黑龙江省口腔病防治院,黑龙江哈尔滨150001 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2013年第9期792-794,共3页Heilongjiang Medical Journal

基　　金：黑龙江省卫生厅科研课题(2011-759)

摘　　要：目的通过检测慢性牙周炎病人牙周基础治疗、丁香叶制剂含漱前后的临床牙周指数和外周血基质金属蛋白酶-8(Matrix metalloproteinase-8,MMP-8)含量的变化,验证牙周基础治疗的有效性,评价丁香叶治疗牙周炎的临床效果。方法 80例中重度慢性牙周炎患者随机分为治疗组和对照组,在牙周基础治疗后,应用丁香叶制剂口腔含漱,观察两组病人牙周指数及血清MMP-8变化情况。结果两组患者牙周炎症均有明显改善,组间比较具有显著性差异。结论丁香叶含漱液通过局部治疗牙周炎症,降低了血液中MMP-8的含量,且同菌斑指数、牙龈指数、牙周袋最大探诊深度,及附着丧失,成正相关性。Objective By detecting periodontal treatment of patients with chronic periodontitis and clove leaf preparation gargle before and after clinical periodontal index and peripheral Matrix metalloproteinase-8 content changes,to verify periodontal therapy effectiveness evaluation of clove leaves to treat periodontitis clinical results.Methods 80 cases of moderate to severe chronic periodontitis patients were randomly divided into treatment group and control group.After periodontal treatment,the application of clove leaf oral rinse formulations were observed in serum of patients MMP-8 periodontal indices and changes were observed through using SPSS statistical software analysis.Results Periodontal disease was significantly improved in both groups,with significant difference.Conclusion Clove leaf gargle,by topical treatment of periodontitis disease,reduces blood levels of MMP-8,and has positive correlation with PLI,GI,PD and AL.

关 键 词：丁香叶 牙周炎 基质金属蛋白酶-8 

分 类 号：R781.4[医药卫生—口腔医学]